The Quality of Recovery From General Anesthesia With Desflurane for Fundus Surgery

Early Phase 1

Not yet recruiting

• Conditions: Postoperative Recovery; Desflurane Anesthesia
• Interventions: Drug: Desflurane Inhalant Product

• Registration Number: NCT06241131
• Lead Sponsor: Sichuan Provincial People's Hospital

Brief Summary

The goal of this clinical trials to study and compare the effects of "desflurane with remifentanil anesthesia (study group)" and "sevoflurane with remifentanil anesthesia (control group)" for elective fundus surgery anesthesia. The main question it aims to answer are the characteristics of desflurane anesthesia in patients undergoing fundus surgery and to provide universal guidance for clinical application.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-12-29
• Status Verified: 2024-01
• Study First Submitted QC: 2024-01-26
• Last Update Submitted: 2024-01-26
• Study First Posted: 2024-02-05
• Last Update Posted: 2024-02-05
• Study Start: 2024-03-01
• Primary Completion: 2024-12-30
• Study Completion: 2025-09-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

1. ASA I-II, patients aged 18-65 years old;
2. Fundus surgery to be performed under general anesthesia ;
3. The expected duration of surgery is about 30-120 min ;
4. BMI: 18-30 kg/m2 ;
5. Those who signed the informed consent form and volunteered to participate in this trial

Exclusion Criteria

1. Patients with known or suspected genetic susceptibility to malignant hyperthermia;
2. Patients with history of asthma;
3. Patients with severe heart diseases (NYHA ≥ III, severe arrhythmia, etc.) and cerebral or pulmonary diseases, liver or kidney dysfunction; or with unstable vital signs;
4. Patients with history of long-term narcotic analgesics application, including sedative and antidepressant drugs;
5. Patients with history of psychotropic drug abuse within 3 months;
6. Patients with long-term alcohol abuse;
7. People with mental disorder and unable to communicate normally;

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sevoflurane with remifentanil anesthesia	Desflurane Inhalant Product	Subjects were randomly assigned to the active comparator group。In this group, sevoflurane was inhaled at a starting concentration of 1 MAC, and remifentanil 0.1 μg/kg/min was continuously pumped intravenously.
desflurane with remifentanil anesthesia	Desflurane Inhalant Product	Subjects were randomly assigned to the experimental group。In this group, desflurane was inhaled at a starting concentration of 1 MAC (Minimal Alveolar Concentration), and remifentanil 0.1 μg/kg/min was continuously pumped intravenously.

Primary Outcome Measures

Name	Time	Method
Recovery time	up to 1 hour	The length of time from stopping anesthesia to patient recovery (opening eyes)