Comparison of Analgesic Effect of Volatile Anesthetics

Phase 3

Completed

• Conditions: Anesthesia
• Interventions: Drug: Desflurane; Drug: Sevoflurane

• Registration Number: NCT02830243
• Lead Sponsor: Kangbuk Samsung Hospital

Brief Summary

The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index.

Detailed Description

Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different bispectral index values. However, the difference between analgesic effects of volatile anesthetics have not yet been investigated. The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index-guided remifentanil infusion.

Study Timeline

• Study First Submitted: 2016-07-09
• Study First Submitted QC: 2016-07-09
• Study Start: 2016-07-12
• Study First Posted: 2016-07-12
• Primary Completion: 2016-10-05
• Study Completion: 2016-10-08
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-13
• Last Update Posted: 2018-05-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• patients undergoing balanced general anesthesia using volatile anesthetics and remifentanil
• patients with american society of anesthesiologist physical status I, II
• patients aged 19-65 years
• patients obtaining written informed consent

Exclusion Criteria

• patients with a history of any psychiatric or neurological disease
• patients who had received any medication affecting the central nervous system
• patients who had received medication affecting the sympathetic or parasympathetic nervous systems
• patients undergoing tracheal intubation for airway management
• pregnant women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane	Desflurane	Anesthesia was maintained with desflurane.
Sevoflurane	Sevoflurane	Anesthesia was maintained with sevoflurane.

Primary Outcome Measures

Name	Time	Method
Remifentanil consumption (µg/kg/min)	During the intraoperative period

Secondary Outcome Measures

Name	Time	Method
Target effective site concentration of remifentanil (ng/ml)	After at least 10 min of stable surgical pleth index values

Trial Locations

Locations (1)

Kangbuk Samsung Hospital; 🇰🇷 Seoul, Korea, Republic of