The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

Phase 3

Completed

• Conditions: Orthopedic Disorders
• Interventions: Drug: Sevoflurane; Drug: Desflurane

• Registration Number: NCT02609802
• Lead Sponsor: Kangbuk Samsung Hospital

Brief Summary

The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Detailed Description

Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetics produced different EEG-derived indices such as bispectral index. However, there was no controlled study that demonstrates the difference of analgesic potency. The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Study Timeline

• Study Start: 2015-11
• Study First Submitted: 2015-11-18
• Study First Submitted QC: 2015-11-18
• Study First Posted: 2015-11-20
• Primary Completion: 2016-07-28
• Study Completion: 2016-07-28
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-06
• Last Update Posted: 2017-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

• patients undergoing arthroscopic shoulder surgery
• patients with american society of anesthesiologist physical status I, II
• patients aged 19-65 years
• patients obtaining written informed consent

Exclusion Criteria

• patients with a history of any psychiatric or neurological disease
• patients who had received any medication affecting the central nervous system
• patients who had received medication affecting the sympathetic or parasympathetic nervous systems
• patients who have not received interscalene approach brachial plexus block (refusal or failure)
• pregnant women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	Anesthesia was maintained with sevoflurane.
Desflurane	Desflurane	Anesthesia was maintained with desflurane.

Primary Outcome Measures

Name	Time	Method
Analgesic potency of volatile anesthetics	the first 60 min of maintaining a steady state 1 MAC of volatile agents	The analgesic potency was evaluated by surgical pleth index value

Trial Locations

Locations (1)

Kangbuk Samsung Hospital; 🇰🇷 Seoul, Korea, Republic of