Comparison of intravenous Magnesium Sulphate combined with Acetaminophen versus intravenous Nalbuphine in COPD patients undergoing elective Cholecystectomy
Not Applicable
Recruiting
- Conditions
- Analgesic efficacy of Non opioid Anaesthesia (NOA).Family history of Asthma and other Chronic lower respiratory diseasesZ82.5
- Registration Number
- IRCT20230819059186N2
- Lead Sponsor
- Combined Military Hospital Rawalpindi Pakistan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 110
Inclusion Criteria
Included all ASA-II and III patients of COPD diagnosed by PFTs (pulmonary function test) with optimized diasease
Patient with age between 45-70 years presenting in the general surgical department for elective cholecystectomy for cholelithiasis.
Exclusion Criteria
Included patients with major cardiac or respiratory disease, low ejection fraction, unoptimized for hypertension or diabetes, patients with cholecystitis
Patients allergic to acetaminophen, MgSO4 or nalbuphine and patients unwilling to be included in the study.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Per-Operative Mean Heart Rate. Timepoint: Mean heart rate (HR) was observed between both groups per-operatively 15 minutes after surgical incision (HR 1) and 15 minutes before extubation (HR 2). Method of measurement: Standard Monitoring with ECG leads attached to the patients.;Per-Operative Mean Arterial Pressure. Timepoint: Mean arterial pressure (MAP) were observed between both groups per-operatively 15 minutes after surgical incision (MAP 1) and 15 minutes before extubation (MAP 2). Method of measurement: Non-Invasive Blood Pressure Measurement.;Time to Rescue Analgesia. Timepoint: Once the pain score on the visual analog scale (VAS) were above 4. Method of measurement: Visual analog scale (VAS).;Post-Operative Analgesic efficacy. Timepoint: Observed at 1,3 & 6 hrs. Method of measurement: Median Pain Score at 1,3 & 6 hrs and Visual analog scale (VAS).
- Secondary Outcome Measures
Name Time Method Post-Operative Respiratory depression. Timepoint: Observed 6hrs post operatively. Method of measurement: Clinical assessment of Respiratory Rate, Pattern of breathing and Oxygen Saturation was observed using Pulse Oximetry.