Effect of Combined Interventions on Pressure Pain Threshold
- Conditions
- Osteo Arthritis Knee
- Interventions
- Procedure: Non end-range mobilizationProcedure: end-range mobilizationProcedure: Control
- Registration Number
- NCT04312035
- Lead Sponsor
- University of Pecs
- Brief Summary
The effect of mobilizations on decrease of peripheral and central sensitivity has been proven in KOA. Furthermore, the effect of conservative therapy has also been proven in the increase of pain threshold in KOA. However, no study has investigated the effect of these interventions combined till date in KOA.
The aim of the present study is to investigate the short-term and long-term effect of end-range mobilization in addition to conservative therapy on decrease of pressure pain threshold in KOA.
- Detailed Description
The positive effect of different manual mobilizations have been proven in the management of knee osteoarthritis (KOA). Pressure pain threshold, as a measure of somatosensory function, is a well-applied measurement technique for the pain perception in KOA. The effect of mobilizations on decrease of peripheral and central sensitivity has been proven in KOA. Furthermore, few studies has revealed the effect of conservative therapy as an effective intervention in the increase of pain threshold. However, no study has investigated the effect of these interventions combined till date in KOA, which could give a long-lasting effect in the decrease of sensitization in KOA.
Therefore, the aim of the present study is to investigate the short-term and long-term effect of end-range mobilization in addition to conservative therapy on decrease of pressure pain threshold in KOA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 60
- clinical classification criteria of knee osteoarthritis according to the American College of Rheumatology
- categorization as End of Range Problem based on Maitland manual therapy
- unilateral/bilateral moderate-to-severe symptomatic tibiofemoral KOA with radiographic evidence of Kellgren-Lawrence scale 2 or 3
- pain during weight-bearing activities at least within 6 months
- at least 90° knee flexion
- sufficient mental status
- acute inflammation of the knee
- total knee replacement in the opposite side
- class II. obesity (body mass index>35kg/m2)
- severe degenerative lumbar spine disease (e.g. spondylolisthesis)
- systemic inflammatory arthritic or neurological condition
- physiotherapy/balneotherapy attendance or manual therapy within 3 months
- intraarticular injections in the prior 12 months
- use of walking aid
- contraindication for manual therapy
- complex regional pain syndrome
- cognitive impairment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Non end-range mobilization Non end-range mobilization Non end-range mobilization performed in loose-packed position of the knee joint End-range mobilization end-range mobilization End-range mobilization performed in end-position of the knee joint Control Control Sham technique performed in loose-packed position of the knee joint
- Primary Outcome Measures
Name Time Method change of peripheral sensitivity following 3-month peripheral sensitivity (pressure pain threshold) assessed at the local knee
- Secondary Outcome Measures
Name Time Method change of central sensitivity following 3-month central sensitivity (pressure pain threshold) assessed at the ipsilateral m. extensor carpi radialis longus
change of Timed Up and Go test following 3-month short test for measuring physical performance
change of pain intensity during physical performance following 3-week rehabilitation pain intensity measured during the previously mentioned physical performance test using the 0-10 Numerating Pain Rating Scale, where 0 indicate no pain and 10 indicate worst imaginable pain
change of pain during physical performance following 3-month pain intensity measured during the previously mentioned physical performance test using the 0-10 Numerating Pain Rating Scale, where 0 indicate no pain and 10 indicate worst imaginable pain
degree of knee flexion during passive movement at the onset of knee pain following 3-month measurement of degree of knee flexion during passive movement at the onset of knee pain
change of general pain intensity following 3-month general pain intensity from the previous week using the Visual Analogue Scale
strength of resistance of passive knee flexion at the onset of knee pain following 3-month measurement of strength of resistance arising from the anterior located tissues around the knee during passive knee flexion at the onset of pain
Trial Locations
- Locations (1)
Miklós Pozsgai
🇭🇺Harkány, Please Select, Hungary