Intubation Time With Low Dose Rocuronium

Not Applicable

Completed

• Conditions: Intubation; Difficult
• Interventions: Drug: Atropine; Drug: Normal saline

• Registration Number: NCT01464489
• Lead Sponsor: Gachon University Gil Medical Center

Brief Summary

The investigators hypothesized that increasing the cardiac output by use of atropine in children might result in a reduction of the intubation time needed to facilitate tracheal intubation.

Detailed Description

The investigators hypothesized that increasing the cardiac output by use of atropine in children might result in a reduction of the intubation time needed to facilitate tracheal intubation. Therefore, the purpose of this study was to determine TimeEI with a low dose of esmeron (rocuronium) (0.3 mg.kg-1) for achievement of successful tracheal intubation conditions during intravenous (i.v.) anaesthesia using propofol and alfentanil in children and to determine whether administration of i.v. atropine (atropine sulphate) (10 μg.kg-1) during anaesthesia induction reduced these times.

Study Timeline

• Study Start: 2011-05
• Primary Completion: 2011-09
• Study Completion: 2011-09
• Study First Submitted: 2011-10-18
• Status Verified: 2011-11
• Study First Submitted QC: 2011-11-01
• Last Update Submitted: 2011-11-01
• Study First Posted: 2011-11-03
• Last Update Posted: 2011-11-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• American Society of Anesthesiologists (ASA) physical status I,
• Tonsillectomy with adenoidectomy

Exclusion Criteria

• Patients with known allergy to the drugs used in this study,
• A history of reactive airway disease and asthma,
• A neuromuscular disorder, an anticipated difficult airway, and
• Crying children on arrival in the operating theatre

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Atropine	Anaesthesia was induced with alfentanil 10 μg.kg-1, propofol 2.5 mg.kg-1 and rocuronium 0.3 mg.kg-1.And receive normal saline for control group
Atropine group	Normal saline	Anaesthesia was induced with alfentanil 10 μg.kg-1, propofol 2.5 mg.kg-1 and rocuronium 0.3 mg.kg-1. And receive atropine (atropine sulfate) 10 μg.kg-1 for atropine group.

Primary Outcome Measures

Name	Time	Method
intubation time	intubating condition at 120 seconds from rocuronium injection	Tracheal intubation was attempted was predetermined according to the up-and-down method, starting with 120 s, in both groups. If intubation was successful (unsuccessful), the assigned intubation time was decreased (increased) by one interval for the next patients in that group, respectively. In this study, the investigators adopted 69, 83, 99, 120, 144, 173, and 208 s, since these intubation times have equal intervals (0.08) on a logarithmic scale.

Trial Locations

Locations (1)

Gachon University Gil Medical Center; 🇰🇷 Incheon, Korea, Republic of