Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease
- Conditions
- Proteinuric Kidney Disease
- Interventions
- Drug: VX-147Drug: Placebo
- Registration Number
- NCT05312879
- Lead Sponsor
- Vertex Pharmaceuticals Incorporated
- Brief Summary
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 466
- APOL1 genotype of G1/G1, G2/G2, or G1/G2
- Proteinuric kidney disease
Key
- Solid organ or bone marrow transplant
- Uncontrolled hypertension
- History of diabetes mellitus
- Known underlying cause of kidney disease including but not limited to sickle cell disease
Other protocol defined Inclusion/Exclusion criteria apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Phase 3: VX-147 VX-147 Participants will receive VX-147 with the dose to be based on the outcome of Phase 2. Phase 3: Placebo Placebo Participants will receive placebo matched to VX-147. Phase 2: VX-147 VX-147 Participants will be randomized to receive different dose levels of VX-147. Phase 2: Placebo Placebo Participants will receive placebo matched to VX-147.
- Primary Outcome Measures
Name Time Method eGFR Slope Assessed at Study Completion From Baseline Through Study Completion (Approximately 2 Years After the Last Participant Enrolls) Percent Change From Baseline in Urine Protein to Creatinine Ratio (UPCR) at Week 48 (Assessed at the Week 48 Interim Analysis) From Baseline at Week 48 Estimated Glomerular Filtration Rate (eGFR) Slope Assessed at the Week 48 Interim Analysis From Baseline Through >= Week 48
- Secondary Outcome Measures
Name Time Method Maximum Plasma Concentration (Cmax) of VX-147 Day 1 and Week 40 Time to Composite Clinical Outcome of a Sustained Decline of >=30 Percent (%) in eGFR, the Onset of end-stage Kidney Disease or Death From Baseline Through Study Completion (Approximately 2 Years After the Last Participant Enrolls) Observed Pre-dose Plasma Concentration (Ctrough) of VX-147 Day 1 up to Week 40 Safety and Tolerability as Assessed by Number of Participants With Adverse events (AEs) and Serious Adverse Events (SAEs) Day 1 Through Study Completion (Approximately 2 Years After the Last Participant Enrolls) Area Under the Concentration Versus Time Curve During a Dosing Interval (AUCtau) of VX-147 Day 1 and Week 40 Acceptability Tablet Formulation of VX-147 in Pediatric Participants using the Convenience Domain of the Treatment Satisfaction Questionnaire for Medication (TSQM) Version 1.4 Day 1 and Week 48
Trial Locations
- Locations (294)
Kings County Hospital
🇺🇸Brooklyn, New York, United States
Prime Clinical Research Inc - Lewisville
🇺🇸Lewisville, Texas, United States
Alabama Kidney Research
🇺🇸Alabaster, Alabama, United States
Cardiology, P.C.
🇺🇸Birmingham, Alabama, United States
Nephrology Associates
🇺🇸Fairhope, Alabama, United States
Nephrology Consultants, LLC
🇺🇸Huntsville, Alabama, United States
Renal Associates of Alabama, LLC
🇺🇸Montgomery, Alabama, United States
EmVenio Research
🇺🇸Chicago, Illinois, United States
AKDHC Medical Research Service LLC - Banner Desert Office
🇺🇸Mesa, Arizona, United States
AKDHC Medical Research Service LLC
🇺🇸Phoenix, Arizona, United States
AMR-Miami
🇺🇸Coral Gables, Florida, United States
Horizon Research Group, LLC
🇺🇸Coral Gables, Florida, United States
South Florida Nephrology Group PA, Research Div.
🇺🇸Coral Springs, Florida, United States
Delray Physician Care Center
🇺🇸Delray Beach, Florida, United States
North Florida/South Georgia Veterans Health System
🇺🇸Gainesville, Florida, United States
University of Florida, Shands Hospital
🇺🇸Gainesville, Florida, United States
Velocity Clinical Research - Hallandale Beach
🇺🇸Hallandale Beach, Florida, United States
Qway Research
🇺🇸Hialeah, Florida, United States
Elixia Pines, LLC
🇺🇸Hollywood, Florida, United States
UF Health Cardiovascular Center - Jacksonville
🇺🇸Jacksonville, Florida, United States
South Florida Research Institute
🇺🇸Lauderdale Lakes, Florida, United States
South Florida Research
🇺🇸Miami Springs, Florida, United States
Total Research Group, LLC
🇺🇸Miami, Florida, United States
Cordova Research Institute
🇺🇸Miami, Florida, United States
MedBio Trials
🇺🇸Miami, Florida, United States
Elixia Central
🇺🇸Orlando, Florida, United States
Omega Research Orlando, LLC
🇺🇸Orlando, Florida, United States
Mid Florida Kidney and Hypertension Care, PL
🇺🇸Sanford, Florida, United States
Genesis Clinical Research
🇺🇸Tampa, Florida, United States
Elixia Tampa, LLC
🇺🇸Tampa, Florida, United States
American Clinical Trials LLC - Acworth
🇺🇸Acworth, Georgia, United States
Emory School of Medicine - Renal Division
🇺🇸Atlanta, Georgia, United States
Advanced Clinical Research of Atlanta
🇺🇸Atlanta, Georgia, United States
Morehouse School of Medicine, Grady Memorial Hospital
🇺🇸Atlanta, Georgia, United States
Children's Healthcare of Atlanta - Center for Advanced Pediatrics
🇺🇸Atlanta, Georgia, United States
Fides Clinical Research
🇺🇸Atlanta, Georgia, United States
Medical College of Georgia (MCG)
🇺🇸Augusta, Georgia, United States
Coastal Medical Research
🇺🇸Brunswick, Georgia, United States
Randomize Now
🇺🇸College Park, Georgia, United States
Clincept - Warm Springs
🇺🇸Columbus, Georgia, United States
Renal Associates, LLC
🇺🇸Columbus, Georgia, United States
Atlanta VA Healthcare System
🇺🇸Decatur, Georgia, United States
American Clinical Trials LLC - Douglasville
🇺🇸Douglasville, Georgia, United States
Southeast Kidney Associates
🇺🇸East Point, Georgia, United States
Javara Inc./Privia Medical Group Georgia, PLLC
🇺🇸Fayetteville, Georgia, United States
Georgia Nephrology
🇺🇸Lawrenceville, Georgia, United States
Javara Inc./Privia Medical Group Georgia, LLC
🇺🇸Savannah, Georgia, United States
Inova Clinical Trials and Research Center
🇺🇸Tyrone, Georgia, United States
Rophe Adult and Pediatric Medicine
🇺🇸Union City, Georgia, United States
AES Chicago (DRS)
🇺🇸Chicago, Illinois, United States
NANI Research LLC
🇺🇸Evergreen Park, Illinois, United States
Renal Physicians of Montgomery County, PA
🇺🇸The Woodlands, Texas, United States
Tranquil Clinical Research
🇺🇸Webster, Texas, United States
Centro de Pesquisa Clinica Professor Salomao Kelner
🇧🇷Recife, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo
🇧🇷Ribeirao Preto, Brazil
Hospital São Lucas
🇧🇷Rio de Janeiro, Brazil
Hospital Universitário Pedro Ernesto
🇧🇷Rio de Janeiro, Brazil
Pedro Ernesto University Hospital
🇧🇷Rio de Janeiro, Brazil
CSB Group of Nephrology Brazil
🇧🇷Salvador, Brazil
Federal University of Bahia
🇧🇷Salvador, Brazil
Hospital Ana Nery/SESAB
🇧🇷Salvador, Brazil
Praxis Pesquisa Medica
🇧🇷Santo Andre, Brazil
Hospital Nove de Julho
🇧🇷Sao Paulo, Brazil
Irmandade Da Santa Casa De Misericordia De Sao Paulo
🇧🇷Sao Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
🇧🇷São José do Rio Preto, Brazil
Hospital do Rim - Fundação Oswaldo Ramos - Ambulatorio NEFRITE
🇧🇷São Paulo, Brazil
University of Sao Paulo
🇧🇷São Paulo, Brazil
Recherche GCP Research
🇨🇦Montreal, Canada
Women's College Hospital
🇨🇦Toronto, Canada
Clinica de La Costa S.A.S
🇨🇴Atlántico, Colombia
Solano & Terront Servicios Medicos SAS - Unidad Integral de Endocrinologia - UNIENDO
🇨🇴Bogota, Colombia
Fundación Valle Del Lili
🇨🇴Cali, Colombia
Centro Cardiovascular Aristides Sotomayor Santa Lucía SAS IPS
🇨🇴Cartagena, Colombia
Mediservis del Tolima IPS S.A.S.
🇨🇴Ibague, Colombia
Promotora Medica Las Americas S.A. - Clinica Las Americas
🇨🇴Medellin, Colombia
Fundación Hospitalaria San Vicente de Paul
🇨🇴Medellín, Colombia
Hopital Henri Mondor
🇫🇷Créteil, France
CHU Grenoble Alpes - Hôpital Nord Michallon
🇫🇷Grenoble, France
CHU de Guadeloupe
🇫🇷Guadeloupe, France
Hopitaux Universitaires Est Parisien - Hopital Tenon
🇫🇷Paris, France
Hôpital Bicêtre AP-HP
🇫🇷Le Kremlin Bicêtre, France
CHU Dupuytren 2
🇫🇷Limoges, France
Hôpital de la Conception, Centre de néphrologie et transplantation rénale
🇫🇷Marseille, France
Ambroise Paré Hospital
🇫🇷Paris, France
Service de Nephrologie - Hopital Universitaire Necker
🇫🇷Paris, France
Université Paris-Descartes / Hôpital Européen Georges Pompidou
🇫🇷Paris, France
AURA Nord Saint Ouen
🇫🇷Saint-Ouen, France
Centre Hospitalier Universitaire CHU de Toulouse Hopital de Rangueil
🇫🇷Toulouse, France
University of Ghana Medical School
🇬🇭Accra, Ghana
The Bank Hospital
🇬🇭Cantonments, Ghana
Komfo Anokye Teaching Hospital
🇬🇭Kumasi, Ghana
University of Amsterdam
🇳🇱Amsterdam, Netherlands
University College Hospital
🇳🇬Agodi, Ibadan, Nigeria
Lagos University Teaching Hospital
🇳🇬Idi-Araba, Nigeria
University of Nigeria Teaching Hospital
🇳🇬Enugu, Nigeria
Lagos State University Teaching Hospital
🇳🇬Ikeja, Nigeria
Nigerian Institute of Medical Research
🇳🇬Yaba, Nigeria
Unidade Autónoma de Nefrologia
🇵🇹Amadora, Portugal
Department of Nephrology and Renal Transplant
🇵🇹Lisboa, Portugal
Hospital Curry Cabral
🇵🇹Lisboa, Portugal
Hospital Beatriz Angelo
🇵🇹Loures, Portugal
Alliance, School of Medicine
🇵🇷Rio Piedras, Puerto Rico
GCM Medical Group, PSC
🇵🇷San Juan, Puerto Rico
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Spain
Reina Sofia University Hospital
🇪🇸Córdoba, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Basildon University Hospital Renal Department
🇬🇧Basildon, United Kingdom
Hospital Universitario Virgen Macarena
🇪🇸Seville, Spain
AES Glasgow (DRS)
🇬🇧Bellshill, United Kingdom
AES Midlands (DRS)
🇬🇧Birmingham, United Kingdom
FutureMeds Birmingham
🇬🇧Birmingham, United Kingdom
University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital
🇬🇧Birmingham, United Kingdom
Epsom and St Helier University Hospitals NHS Trust - St Helier Hospital - South West SW Thames Institute for Renal Research
🇬🇧Carshalton, United Kingdom
University Hospitals of Leicester NHS Trust - Leicester General Hospital
🇬🇧Leicester, United Kingdom
Barts Health NHS Trust, The Royal London Hospital
🇬🇧London, United Kingdom
Guy's & St Thomas NHS Foundation Trust, Guy's Hospital
🇬🇧London, United Kingdom
Royal Free NHS Trust
🇬🇧London, United Kingdom
St George's University Hospitals NHS Foundation Trust
🇬🇧London, United Kingdom
Great Ormond Street Hospital for Children
🇬🇧London, United Kingdom
St Pancras Clinical Research
🇬🇧London, United Kingdom
AES NW Consortium Manchester (DRS)
🇬🇧Manchester, United Kingdom
The Medicines Evaluation Unit
🇬🇧Manchester, United Kingdom
Nottingham University Hospital
🇬🇧Nottingham, United Kingdom
King's College Hospital NHS Foundation Trust - Guthrie Clinic
🇬🇧Southwark, United Kingdom
Manchester Royal Infirmary
🇬🇧Manchester, United Kingdom
Accelerated Enrollment Solutions (AES) Orlando
🇺🇸Orlando, Florida, United States
Phoenix Children's Hospital, Inc.
🇺🇸Phoenix, Arizona, United States
Cardiology and Medicine Clinic, P.A.
🇺🇸Little Rock, Arkansas, United States
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
The Medical Research Group, Inc
🇺🇸Fresno, California, United States
Amicis Research Center
🇺🇸Granada Hills, California, United States
Renal Consultants Medical Group
🇺🇸Granada Hills, California, United States
Eastside Clinical Research Associates
🇺🇸Los Angeles, California, United States
Kaiser Permanente - Los Angeles Medical Center
🇺🇸Los Angeles, California, United States
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
UCLA Division of Nephrology
🇺🇸Los Angeles, California, United States
UCI Center for Clinical Research
🇺🇸Orange, California, United States
Kaiser Permanente, Sacramento
🇺🇸Sacramento, California, United States
UCSF School of Medicine
🇺🇸San Francisco, California, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
🇺🇸Torrance, California, United States
Kidney and Hypertension Center
🇺🇸Victorville, California, United States
Greater Hartford Nephrology
🇺🇸Bloomfield, Connecticut, United States
Nephrology & Hypertension Associates, PC
🇺🇸Middlebury, Connecticut, United States
Yale University
🇺🇸New Haven, Connecticut, United States
Children's National Hospital
🇺🇸Washington, District of Columbia, United States
The George Washington University Medical Faculty Associates - Kidney Disease & Hypertension
🇺🇸Washington, District of Columbia, United States
Bay Pines Healthcare System
🇺🇸Bay Pines, Florida, United States
Nova Clinical Research, LLC
🇺🇸Bradenton, Florida, United States
Clinical Research of Brandon, LLC
🇺🇸Brandon, Florida, United States
Edward Hines Jr VA Hospital
🇺🇸Hines, Illinois, United States
Essential Concepts Research Solutions
🇺🇸Palos Hills, Illinois, United States
NANI Research LLC - Indiana
🇺🇸Fort Wayne, Indiana, United States
Indiana University
🇺🇸Indianapolis, Indiana, United States
Nephrology Physicians, LLC
🇺🇸Mishawaka, Indiana, United States
University of Iowa
🇺🇸Iowa City, Iowa, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Premier Clinical Research
🇺🇸Overland Park, Kansas, United States
Renal Associates of Baton Rouge
🇺🇸Baton Rouge, Louisiana, United States
East Jefferson General Hospital
🇺🇸Metairie, Louisiana, United States
Barnum Medical Research
🇺🇸Natchitoches, Louisiana, United States
Louisiana State University Health Sciences Center LSUHSC
🇺🇸New Orleans, Louisiana, United States
University Medical Center - New Orleans
🇺🇸New Orleans, Louisiana, United States
Ochsner Medical Center - New Orleans
🇺🇸New Orleans, Louisiana, United States
Northwest Louisiana Nephrology, LLC - Shreveport
🇺🇸Shreveport, Louisiana, United States
Monroe Research, LLC
🇺🇸West Monroe, Louisiana, United States
Javara Inc./Privia Medical Group, LLC MidAtlantic - Main Research Site
🇺🇸Annapolis, Maryland, United States
University of Maryland Medical Center
🇺🇸Baltimore, Maryland, United States
Johns Hopkins Hospital
🇺🇸Baltimore, Maryland, United States
Kaiser Permanente, Mid-Atlantic
🇺🇸Gaithersburg, Maryland, United States
Patient First Clinical Trials
🇺🇸Nottingham, Maryland, United States
MD Medical Research
🇺🇸Oxon Hill, Maryland, United States
Javara Inc./Privia Medical Group, LLC MidAtlantic-Silver Spring, MD
🇺🇸Silver Spring, Maryland, United States
Tufts Medical Center
🇺🇸Boston, Massachusetts, United States
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Whittier Street Health Center
🇺🇸Roxbury, Massachusetts, United States
Renal and Transplant Associates of New England, PC
🇺🇸Springfield, Massachusetts, United States
Kidney Care and Transplant Services of New England
🇺🇸West Springfield, Massachusetts, United States
University of Michigan Health System - A. Alfred Taubman Health Care Center - Nephrology Clinic
🇺🇸Ann Arbor, Michigan, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
AA Medical Research Center
🇺🇸Flint, Michigan, United States
Sparrow Clinical Research Institute
🇺🇸Lansing, Michigan, United States
St. Clair Nephrology Research
🇺🇸Roseville, Michigan, United States
Center for Advanced Kidney Research
🇺🇸Saint Clair Shores, Michigan, United States
InterMed Consultants/ Davita Clinical Research
🇺🇸Edina, Minnesota, United States
Minneapolis VA Healthcare System
🇺🇸Minneapolis, Minnesota, United States
Nephrology Associates, P.C.
🇺🇸Columbus, Mississippi, United States
University of Mississippi
🇺🇸Grenada, Mississippi, United States
Olive Branch Family Medical Center
🇺🇸Olive Branch, Mississippi, United States
Nephrology and Hypertension Associates, LTD
🇺🇸Tupelo, Mississippi, United States
Center for Specialized Medicine - SSM Health Saint Louis University Hospital
🇺🇸Saint Louis, Missouri, United States
Washington University Saint Louis
🇺🇸Saint Louis, Missouri, United States
St. Louis Heart and Vascular, P.C.
🇺🇸Saint Louis, Missouri, United States
Nevada Kidney Disease and Hypertension Centers
🇺🇸Las Vegas, Nevada, United States
DaVita Clinical Research
🇺🇸Las Vegas, Nevada, United States
Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Rutgers New Jersey Medical School
🇺🇸Newark, New Jersey, United States
New Mexico VA Healthcare System
🇺🇸Albuquerque, New Mexico, United States
Renal Medicine Associates
🇺🇸Albuquerque, New Mexico, United States
Albert Einstein Hospital - Montefiore Medical Center
🇺🇸Bronx, New York, United States
Kidney Medical Associates, PLLC
🇺🇸Bronx, New York, United States
Montefiore Medical Center
🇺🇸Bronx, New York, United States
James J. Peters VA Medical Center
🇺🇸Bronx, New York, United States
SUNY Downstate Health Sciences University
🇺🇸Brooklyn, New York, United States
Clindove Research LLC
🇺🇸Brooklyn, New York, United States
Nephrology Associates, P.C. - Queens
🇺🇸Flushing, New York, United States
Zucker School of Medicine at Hofstra/Northwell
🇺🇸Great Neck, New York, United States
Clinical Research Development Associates LLC
🇺🇸Laurelton, New York, United States
VA New York Harbor Healthcare System
🇺🇸New York, New York, United States
New York University Grossman School of Medicine
🇺🇸New York, New York, United States
AES New York (DRS)
🇺🇸New York, New York, United States
The Rogosin Institute - The Rogosin Kidney Center
🇺🇸New York, New York, United States
Icahn School of Medicine at Mount Sinai
🇺🇸New York, New York, United States
Columbia University - Division of Nephrology
🇺🇸New York, New York, United States
NYC Health + Hospital/Harlem
🇺🇸New York, New York, United States
North Carolina Nephrology P.A. - Cary Office
🇺🇸Cary, North Carolina, United States
UNC Clinical and Translational Research Center
🇺🇸Chapel Hill, North Carolina, United States
Metrolina Nephrology Associates
🇺🇸Charlotte, North Carolina, United States
DUHS Children's Health Center T0909
🇺🇸Durham, North Carolina, United States
Eastern Nephrology Associates - Greenville Office
🇺🇸Greenville, North Carolina, United States
Eastern Nephrology Associates - Jacksonville Office
🇺🇸Jacksonville, North Carolina, United States
Eastern Nephrology Associates - Kinston Office
🇺🇸Kinston, North Carolina, United States
Eastern Nephrology Associates - New Bern Office
🇺🇸New Bern, North Carolina, United States
Eastern Nephrology Associates - Wilmington Office
🇺🇸Wilmington, North Carolina, United States
Brookview Hills Research Associates
🇺🇸Winston-Salem, North Carolina, United States
University of Cincinnati College of Medicine
🇺🇸Cincinnati, Ohio, United States
Cincinnati VA Medical Center
🇺🇸Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
VA Cleveland Northeast Ohio Healthcare System
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
Ohio State University
🇺🇸Columbus, Ohio, United States
Thomas Jefferson University
🇺🇸Philadelphia, Pennsylvania, United States
Einstein Medical Center (NDKD)
🇺🇸Philadelphia, Pennsylvania, United States
Children's Hospital of Pittsburgh of UPMC
🇺🇸Pittsburgh, Pennsylvania, United States
Temple University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Lifespan Clinical Research Center
🇺🇸East Providence, Rhode Island, United States
Pharmacorp Clinical Trials, Inc
🇺🇸Charleston, South Carolina, United States
Medical University of South Carolina - Nexus Research Clinic
🇺🇸Charleston, South Carolina, United States
Columbia Nephrology Associates, PA
🇺🇸Columbia, South Carolina, United States
Carolina Nephrology, PA
🇺🇸Spartanburg, South Carolina, United States
Southeast Renal Research Institute
🇺🇸Chattanooga, Tennessee, United States
Nephrotex Research Group/Texas Kidney Institute
🇺🇸Dallas, Texas, United States
Le Bonheur Children's Hospital - Outpatient Clinic
🇺🇸Memphis, Tennessee, United States
Clinical Neuroscience Solutions (CNS Healthcare) - Memphis Research Center
🇺🇸Memphis, Tennessee, United States
Meharry Medical College
🇺🇸Nashville, Tennessee, United States
Vanderbilt University Medical Center, Nephrology Clinical Trials Center
🇺🇸Nashville, Tennessee, United States
Dallas Renal Group - Arlington
🇺🇸Arlington, Texas, United States
Arlington Nephrology
🇺🇸Arlington, Texas, United States
Baylor Scott & White Research Institute
🇺🇸Dallas, Texas, United States
Dallas Renal Group - 2
🇺🇸Dallas, Texas, United States
Dallas Renal Group - 1
🇺🇸Dallas, Texas, United States
Dallas Nephrology Associates - Dallas Landry Office
🇺🇸Dallas, Texas, United States
Southwest Family Medicine Associates (SFMA) - Dallas
🇺🇸Dallas, Texas, United States
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Davita Clinical Research - El Paso
🇺🇸El Paso, Texas, United States
Cook Children's Medical Center
🇺🇸Fort Worth, Texas, United States
Ronald Ralph MD PA
🇺🇸Houston, Texas, United States
Prolato Clinical Research Center
🇺🇸Houston, Texas, United States
Houston Medical Research Institute, LLC
🇺🇸Houston, Texas, United States
Clinical Research Strategies - Romano North Main Office
🇺🇸Houston, Texas, United States
Southwest Houston Research, Ltd
🇺🇸Houston, Texas, United States
North Texas Kidney Disease Associates
🇺🇸Lewisville, Texas, United States
Prime Clinical Research
🇺🇸Mansfield, Texas, United States
Texas Tech University Health Sciences Center
🇺🇸Lubbock, Texas, United States
San Antonio Kidney
🇺🇸San Antonio, Texas, United States
University of Texas Health San Antonio
🇺🇸San Antonio, Texas, United States
Kidney Specialists of N Houston, PLLC
🇺🇸Shenandoah, Texas, United States
University of Virginia Health - Nephrology Clinical Research Center
🇺🇸Charlottesville, Virginia, United States
TKS Research, P.L.L.C.
🇺🇸Norfolk, Virginia, United States
York Clinical Research, LLC
🇺🇸Norfolk, Virginia, United States
Richmond VAMC
🇺🇸Richmond, Virginia, United States
Virginia Commonwealth University - Division of Nephrology
🇺🇸Richmond, Virginia, United States
Nephrology Associates of Tidewater, LTD
🇺🇸Virginia Beach, Virginia, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Milwaukee Nephrologists, SC
🇺🇸Wauwatosa, Wisconsin, United States
Cliniques Universitaires Saint-Luc
🇧🇪Woluwe-Saint-Lambert, Brussels, Belgium
University Hospital Leuven
🇧🇪Leuven, Belgium
Centro de Pesquisa Clinica do Coracao
🇧🇷Aracaju, Brazil
Santa Casa de Misericórdia de Belo Horizonte
🇧🇷Belo Horizonte, Brazil
Upeclin - UNESP Botucatu - CKD and Hypertension Department
🇧🇷Botucatu, Brazil
Upeclin - UNESP Botucatu - Kidney Transplantation Department
🇧🇷Botucatu, Brazil
IPECC - Instituto de Pesquisa Clinica de Campinas
🇧🇷Campinas, Brazil
Instituto Pro-Renal
🇧🇷Curitiba, Brazil
PUC Trials - Unidade Epicenter
🇧🇷Curitiba, Brazil
Hospital Universitário Valter Cantídio
🇧🇷Fortaleza, Brazil
Federal University of Goiás (UFG)
🇧🇷Goiania, Brazil
Cmip-Centro Mineiro de Pesquisa Ltda
🇧🇷Juiz de Fora, Brazil
Galileo Medical Research Ltda
🇧🇷Juiz De Fora, Brazil
ICM - Instituto do Coracao de Marilia
🇧🇷Marilia, Brazil
Instituto de Ensino e Pesquisa Clinica do Ceara
🇧🇷Meireles, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre
🇧🇷Porto Alegre, Brazil
UFRS - Hospital de Clínicas
🇧🇷Porto Alegre, Brazil