Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease

Phase 2

Recruiting

• Conditions: Proteinuric Kidney Disease
• Interventions: Drug: VX-147; Drug: Placebo

• Registration Number: NCT05312879
• Lead Sponsor: Vertex Pharmaceuticals Incorporated

Brief Summary

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-28
• Study First Submitted QC: 2022-03-28
• Study Start: 2022-03-30
• Study First Posted: 2022-04-06
• Status Verified: 2024-09
• Last Update Submitted: 2025-05-16
• Last Update Posted: 2025-05-18
• Primary Completion: 2026-05-31
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 466

Inclusion Criteria

• APOL1 genotype of G1/G1, G2/G2, or G1/G2
• Proteinuric kidney disease

Key

Exclusion Criteria

• Solid organ or bone marrow transplant
• Uncontrolled hypertension
• History of diabetes mellitus
• Known underlying cause of kidney disease including but not limited to sickle cell disease

Other protocol defined Inclusion/Exclusion criteria apply.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Phase 3: VX-147	VX-147	Participants will receive VX-147 with the dose to be based on the outcome of Phase 2.
Phase 3: Placebo	Placebo	Participants will receive placebo matched to VX-147.
Phase 2: VX-147	VX-147	Participants will be randomized to receive different dose levels of VX-147.
Phase 2: Placebo	Placebo	Participants will receive placebo matched to VX-147.

Primary Outcome Measures

Name	Time	Method
eGFR Slope Assessed at Study Completion	From Baseline Through Study Completion (Approximately 2 Years After the Last Participant Enrolls)
Percent Change From Baseline in Urine Protein to Creatinine Ratio (UPCR) at Week 48 (Assessed at the Week 48 Interim Analysis)	From Baseline at Week 48
Estimated Glomerular Filtration Rate (eGFR) Slope Assessed at the Week 48 Interim Analysis	From Baseline Through >= Week 48

Secondary Outcome Measures

Name	Time	Method
Time to Composite Clinical Outcome of a Sustained Decline of >=30 Percent (%) in eGFR, the Onset of end-stage Kidney Disease or Death	From Baseline Through Study Completion (Approximately 2 Years After the Last Participant Enrolls)
Safety and Tolerability as Assessed by Number of Participants With Adverse events (AEs) and Serious Adverse Events (SAEs)	Day 1 Through Study Completion (Approximately 2 Years After the Last Participant Enrolls)
Maximum Plasma Concentration (Cmax) of VX-147	Day 1 and Week 40
Area Under the Concentration Versus Time Curve During a Dosing Interval (AUCtau) of VX-147	Day 1 and Week 40
Observed Pre-dose Plasma Concentration (Ctrough) of VX-147	Day 1 up to Week 40
Acceptability Tablet Formulation of VX-147 in Pediatric Participants using the Convenience Domain of the Treatment Satisfaction Questionnaire for Medication (TSQM) Version 1.4	Day 1 and Week 48

Trial Locations

Locations (311)

Praxis Pesquisa Medica; 🇧🇷 Santo Andre, Brazil

Hospital Nove de Julho; 🇧🇷 Sao Paulo, Brazil

Cordova Research Institute; 🇺🇸 Miami, Florida, United States

Georgia Nephrology; 🇺🇸 Lawrenceville, Georgia, United States

Washington University Saint Louis; 🇺🇸 Saint Louis, Missouri, United States

Instituto Pro-Renal; 🇧🇷 Curitiba, Brazil

UCSF School of Medicine; 🇺🇸 San Francisco, California, United States

PUC Trials - Unidade Epicenter; 🇧🇷 Curitiba, Brazil

Alabama Kidney Research; 🇺🇸 Alabaster, Alabama, United States

EmVenio Research; 🇺🇸 Chicago, Illinois, United States

Cardiology, P.C.; 🇺🇸 Birmingham, Alabama, United States

Children's Hospital of Alabama; 🇺🇸 Birmingham, Alabama, United States

University of Alabama at Birmingham - The Kirklin Clinic; 🇺🇸 Birmingham, Alabama, United States

Nephrology Associates; 🇺🇸 Fairhope, Alabama, United States

Heart Center Research LLC; 🇺🇸 Huntsville, Alabama, United States

Nephrology Consultants, LLC; 🇺🇸 Huntsville, Alabama, United States

Renal Associates of Alabama, LLC; 🇺🇸 Montgomery, Alabama, United States

AKDHC Medical Research Service LLC - Banner Desert Office; 🇺🇸 Mesa, Arizona, United States

AKDHC Medical Research Service LLC; 🇺🇸 Phoenix, Arizona, United States

Phoenix Children's Hospital, Inc.; 🇺🇸 Phoenix, Arizona, United States

Cardiology and Medicine Clinic, P.A.; 🇺🇸 Little Rock, Arkansas, United States

University of Arkansas for Medical Sciences; 🇺🇸 Little Rock, Arkansas, United States

The Medical Research Group, Inc; 🇺🇸 Fresno, California, United States

Amicis Research Center; 🇺🇸 Granada Hills, California, United States

Renal Consultants Medical Group; 🇺🇸 Granada Hills, California, United States

Eastside Clinical Research Associates; 🇺🇸 Los Angeles, California, United States

Kaiser Permanente - Los Angeles Medical Center; 🇺🇸 Los Angeles, California, United States

Cedars-Sinai Medical Center; 🇺🇸 Los Angeles, California, United States

UCLA Division of Nephrology; 🇺🇸 Los Angeles, California, United States

UCI Center for Clinical Research; 🇺🇸 Orange, California, United States

Kaiser Permanente, Sacramento; 🇺🇸 Sacramento, California, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; 🇺🇸 Torrance, California, United States

Kidney and Hypertension Center; 🇺🇸 Victorville, California, United States

Greater Hartford Nephrology; 🇺🇸 Bloomfield, Connecticut, United States

Nephrology & Hypertension Associates, PC; 🇺🇸 Middlebury, Connecticut, United States

Yale University; 🇺🇸 New Haven, Connecticut, United States

Children's National Hospital; 🇺🇸 Washington, District of Columbia, United States

The George Washington University Medical Faculty Associates - Kidney Disease & Hypertension; 🇺🇸 Washington, District of Columbia, United States

Bay Pines Healthcare System; 🇺🇸 Bay Pines, Florida, United States

Nova Clinical Research, LLC; 🇺🇸 Bradenton, Florida, United States

Clinical Research of Brandon, LLC; 🇺🇸 Brandon, Florida, United States

AMR-Miami; 🇺🇸 Coral Gables, Florida, United States

Horizon Research Group, LLC; 🇺🇸 Coral Gables, Florida, United States

South Florida Nephrology Group PA, Research Div.; 🇺🇸 Coral Springs, Florida, United States

Delray Physician Care Center; 🇺🇸 Delray Beach, Florida, United States

North Florida/South Georgia Veterans Health System; 🇺🇸 Gainesville, Florida, United States

University of Florida, Shands Hospital; 🇺🇸 Gainesville, Florida, United States

Velocity Clinical Research - Hallandale Beach; 🇺🇸 Hallandale Beach, Florida, United States

Qway Research; 🇺🇸 Hialeah, Florida, United States

Elixia Pines, LLC; 🇺🇸 Hollywood, Florida, United States

UF Health Cardiovascular Center - Jacksonville; 🇺🇸 Jacksonville, Florida, United States

South Florida Research Institute; 🇺🇸 Lauderdale Lakes, Florida, United States

South Florida Research; 🇺🇸 Miami Springs, Florida, United States

Total Research Group, LLC; 🇺🇸 Miami, Florida, United States

MedBio Trials; 🇺🇸 Miami, Florida, United States

Accelerated Enrollment Solutions (AES) Orlando; 🇺🇸 Orlando, Florida, United States

ClinTrials Research (CTR) - FL; 🇺🇸 Orlando, Florida, United States

Omega Research Orlando, LLC; 🇺🇸 Orlando, Florida, United States

Infigo Clinical Research; 🇺🇸 Sanford, Florida, United States

Genesis Clinical Research; 🇺🇸 Tampa, Florida, United States

Elixia Tampa, LLC; 🇺🇸 Tampa, Florida, United States

American Clinical Trials LLC - Acworth; 🇺🇸 Acworth, Georgia, United States

Emory School of Medicine - Renal Division; 🇺🇸 Atlanta, Georgia, United States

Advanced Clinical Research of Atlanta; 🇺🇸 Atlanta, Georgia, United States

Morehouse School of Medicine, Grady Memorial Hospital; 🇺🇸 Atlanta, Georgia, United States

Children's Healthcare of Atlanta - Center for Advanced Pediatrics; 🇺🇸 Atlanta, Georgia, United States

AES Atlanta (DRS); 🇺🇸 Atlanta, Georgia, United States

Fides Clinical Research; 🇺🇸 Atlanta, Georgia, United States

Augusta University Medical College of Georgia - Adult Sickle Cell Clinic; 🇺🇸 Augusta, Georgia, United States

Coastal Medical Research; 🇺🇸 Brunswick, Georgia, United States

Randomize Now; 🇺🇸 College Park, Georgia, United States

Clincept - Warm Springs; 🇺🇸 Columbus, Georgia, United States

Renal Associates, LLC; 🇺🇸 Columbus, Georgia, United States

Atlanta VA Healthcare System; 🇺🇸 Decatur, Georgia, United States

American Clinical Trials LLC - Douglasville; 🇺🇸 Douglasville, Georgia, United States

Southeast Kidney Associates; 🇺🇸 East Point, Georgia, United States

Javara Inc./Privia Medical Group Georgia, PLLC; 🇺🇸 Fayetteville, Georgia, United States

Javara Inc./Privia Medical Group Georgia, LLC; 🇺🇸 Savannah, Georgia, United States

Inova Clinical Trials and Research Center; 🇺🇸 Tyrone, Georgia, United States

Rophe Adult and Pediatric Medicine; 🇺🇸 Union City, Georgia, United States

AES Chicago (DRS); 🇺🇸 Chicago, Illinois, United States

EmVenio Research - Chicago; 🇺🇸 Chicago, Illinois, United States

Northwestern University; 🇺🇸 Chicago, Illinois, United States

University of Chicago; 🇺🇸 Chicago, Illinois, United States

NANI Research LLC; 🇺🇸 Evergreen Park, Illinois, United States

Edward Hines Jr VA Hospital; 🇺🇸 Hines, Illinois, United States

Essential Concepts Research Solutions; 🇺🇸 Palos Hills, Illinois, United States

NANI Research LLC - Indiana; 🇺🇸 Fort Wayne, Indiana, United States

Indiana University; 🇺🇸 Indianapolis, Indiana, United States

Nephrology Physicians, LLC; 🇺🇸 Mishawaka, Indiana, United States

University of Iowa; 🇺🇸 Iowa City, Iowa, United States

University of Kansas Medical Center; 🇺🇸 Kansas City, Kansas, United States

Premier Clinical Research; 🇺🇸 Overland Park, Kansas, United States

Renal Associates of Baton Rouge; 🇺🇸 Baton Rouge, Louisiana, United States

East Jefferson General Hospital; 🇺🇸 Metairie, Louisiana, United States

Barnum Medical Research; 🇺🇸 Natchitoches, Louisiana, United States

Louisiana State University Health Sciences Center LSUHSC; 🇺🇸 New Orleans, Louisiana, United States

University Medical Center - New Orleans; 🇺🇸 New Orleans, Louisiana, United States

Ochsner Medical Center - New Orleans; 🇺🇸 New Orleans, Louisiana, United States

Northwest Louisiana Nephrology, LLC - Shreveport; 🇺🇸 Shreveport, Louisiana, United States

Louisiana State University Health Shreveport; 🇺🇸 Shreveport, Louisiana, United States

Monroe Research, LLC; 🇺🇸 West Monroe, Louisiana, United States

Javara Inc./Privia Medical Group, LLC MidAtlantic - Main Research Site; 🇺🇸 Annapolis, Maryland, United States

General Clinical Research Center, University of Maryland Baltimore; 🇺🇸 Baltimore, Maryland, United States

Johns Hopkins Hospital; 🇺🇸 Baltimore, Maryland, United States

Kaiser Permanente, Mid-Atlantic; 🇺🇸 Gaithersburg, Maryland, United States

Patient First Clinical Trials; 🇺🇸 Nottingham, Maryland, United States

MD Medical Research; 🇺🇸 Oxon Hill, Maryland, United States

Javara Inc./Privia Medical Group, LLC MidAtlantic-Silver Spring, MD; 🇺🇸 Silver Spring, Maryland, United States

Tufts Medical Center; 🇺🇸 Boston, Massachusetts, United States

Boston Medical Center; 🇺🇸 Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center; 🇺🇸 Boston, Massachusetts, United States

Whittier Street Health Center; 🇺🇸 Roxbury, Massachusetts, United States

Renal and Transplant Associates of New England, PC; 🇺🇸 Springfield, Massachusetts, United States

Kidney Care and Transplant Services of New England; 🇺🇸 West Springfield, Massachusetts, United States

University of Michigan Health System - A. Alfred Taubman Health Care Center - Nephrology Clinic; 🇺🇸 Ann Arbor, Michigan, United States

Henry Ford Hospital; 🇺🇸 Detroit, Michigan, United States

Quest Research Institute; 🇺🇸 Farmington Hills, Michigan, United States

AA Medical Research Center; 🇺🇸 Flint, Michigan, United States

Sparrow Clinical Research Institute; 🇺🇸 Lansing, Michigan, United States

St. Clair Nephrology Research; 🇺🇸 Roseville, Michigan, United States

Center for Advanced Kidney Research; 🇺🇸 Saint Clair Shores, Michigan, United States

InterMed Consultants/ Davita Clinical Research; 🇺🇸 Edina, Minnesota, United States

Minneapolis VA Healthcare System; 🇺🇸 Minneapolis, Minnesota, United States

Nephrology Associates, P.C.; 🇺🇸 Columbus, Mississippi, United States

Prime Health and Wellness; 🇺🇸 Fayette, Mississippi, United States

University of Mississippi; 🇺🇸 Grenada, Mississippi, United States

G.V. (Sonny) Montgomery VAMC; 🇺🇸 Jackson, Mississippi, United States

Olive Branch Family Medical Center; 🇺🇸 Olive Branch, Mississippi, United States

SKY Integrative Medical Center; 🇺🇸 Ridgeland, Mississippi, United States

Nephrology and Hypertension Associates, LTD; 🇺🇸 Tupelo, Mississippi, United States

Center for Specialized Medicine - SSM Health Saint Louis University Hospital; 🇺🇸 Saint Louis, Missouri, United States

Washington University School of Medicine - ADULT; 🇺🇸 Saint Louis, Missouri, United States

St. Louis Heart and Vascular, P.C.; 🇺🇸 Saint Louis, Missouri, United States

Nevada Kidney Disease and Hypertension Centers; 🇺🇸 Las Vegas, Nevada, United States

DaVita Clinical Research; 🇺🇸 Las Vegas, Nevada, United States

Cooper University Healthcare; 🇺🇸 Camden, New Jersey, United States

Hackensack University Medical Center; 🇺🇸 Hackensack, New Jersey, United States

Bioluminux Clinical Research New Jersey; 🇺🇸 Hamilton, New Jersey, United States

Rutgers New Jersey Medical School; 🇺🇸 Newark, New Jersey, United States

New Mexico VA Healthcare System; 🇺🇸 Albuquerque, New Mexico, United States

Renal Medicine Associates; 🇺🇸 Albuquerque, New Mexico, United States

Albert Einstein Hospital - Montefiore Medical Center; 🇺🇸 Bronx, New York, United States

Kidney Medical Associates, PLLC; 🇺🇸 Bronx, New York, United States

Montefiore Medical Center; 🇺🇸 Bronx, New York, United States

James J. Peters VA Medical Center; 🇺🇸 Bronx, New York, United States

Kings County Hospital; 🇺🇸 Brooklyn, New York, United States

SUNY Downstate Health Sciences University; 🇺🇸 Brooklyn, New York, United States

Clindove Research LLC; 🇺🇸 Brooklyn, New York, United States

Nephrology Associates, P.C. - Queens; 🇺🇸 Flushing, New York, United States

Zucker School of Medicine at Hofstra/Northwell; 🇺🇸 Great Neck, New York, United States

Scott Research, Inc.; 🇺🇸 Laurelton, New York, United States

VA New York Harbor Healthcare System; 🇺🇸 New York, New York, United States

New York University Grossman School of Medicine; 🇺🇸 New York, New York, United States

AES New York (DRS); 🇺🇸 New York, New York, United States

The Rogosin Institute - The Rogosin Kidney Center; 🇺🇸 New York, New York, United States

Icahn School of Medicine at Mount Sinai; 🇺🇸 New York, New York, United States

Columbia University - Division of Nephrology; 🇺🇸 New York, New York, United States

NYC Health + Hospital/Harlem; 🇺🇸 New York, New York, United States

North Carolina Nephrology P.A. - Cary Office; 🇺🇸 Cary, North Carolina, United States

UNC Clinical and Translational Research Center; 🇺🇸 Chapel Hill, North Carolina, United States

Metrolina Nephrology Associates; 🇺🇸 Charlotte, North Carolina, United States

DUHS Children's Health Center T0909; 🇺🇸 Durham, North Carolina, United States

Eastern Nephrology Associates - Greenville Office; 🇺🇸 Greenville, North Carolina, United States

Eastern Nephrology Associates - Jacksonville Office; 🇺🇸 Jacksonville, North Carolina, United States

Eastern Nephrology Associates - Kinston Office; 🇺🇸 Kinston, North Carolina, United States

Eastern Nephrology Associates - New Bern Office; 🇺🇸 New Bern, North Carolina, United States

Federal University of Bahia; 🇧🇷 Salvador, Brazil

Eastern Nephrology Associates - Wilmington Office; 🇺🇸 Wilmington, North Carolina, United States

Brookview Hills Research Associates; 🇺🇸 Winston-Salem, North Carolina, United States

University of Cincinnati College of Medicine; 🇺🇸 Cincinnati, Ohio, United States

Cincinnati VA Medical Center; 🇺🇸 Cincinnati, Ohio, United States

University Hospitals Cleveland Medical Center; 🇺🇸 Cleveland, Ohio, United States

VA Cleveland Northeast Ohio Healthcare System; 🇺🇸 Cleveland, Ohio, United States

Cleveland Clinic; 🇺🇸 Cleveland, Ohio, United States

Ohio State University; 🇺🇸 Columbus, Ohio, United States

Thomas Jefferson University; 🇺🇸 Philadelphia, Pennsylvania, United States

Temple University Hospital; 🇺🇸 Philadelphia, Pennsylvania, United States

Einstein Medical Center (NDKD); 🇺🇸 Philadelphia, Pennsylvania, United States

Children's Hospital of Pittsburgh of UPMC; 🇺🇸 Pittsburgh, Pennsylvania, United States

Lifespan Clinical Research Center; 🇺🇸 East Providence, Rhode Island, United States

Pharmacorp Clinical Trials, Inc; 🇺🇸 Charleston, South Carolina, United States

Medical University of South Carolina - Nexus Research Clinic; 🇺🇸 Charleston, South Carolina, United States

Columbia Nephrology Associates, PA; 🇺🇸 Columbia, South Carolina, United States

Carolina Nephrology, PA; 🇺🇸 Spartanburg, South Carolina, United States

Southeast Renal Research Institute; 🇺🇸 Chattanooga, Tennessee, United States

Le Bonheur Children's Hospital - Outpatient Clinic; 🇺🇸 Memphis, Tennessee, United States

Clinical Neuroscience Solutions (CNS Healthcare) - Memphis Research Center; 🇺🇸 Memphis, Tennessee, United States

Meharry Medical College; 🇺🇸 Nashville, Tennessee, United States

Nashville VA Medical Center; 🇺🇸 Nashville, Tennessee, United States

Vanderbilt University Medical Center, Nephrology Clinical Trials Center; 🇺🇸 Nashville, Tennessee, United States

Dallas Renal Group - Arlington; 🇺🇸 Arlington, Texas, United States

Arlington Nephrology; 🇺🇸 Arlington, Texas, United States

Baylor Scott & White Research Institute; 🇺🇸 Dallas, Texas, United States

Zenos Clinical Research; 🇺🇸 Dallas, Texas, United States

Nephrotex Research Group/Texas Kidney Institute; 🇺🇸 Dallas, Texas, United States

Dallas Renal Group - 1; 🇺🇸 Dallas, Texas, United States

Dallas Nephrology Associates - Dallas Landry Office; 🇺🇸 Dallas, Texas, United States

Hospital Ana Nery/SESAB; 🇧🇷 Salvador, Brazil

Southwest Family Medicine Associates (SFMA) - Dallas; 🇺🇸 Dallas, Texas, United States

UT Southwestern Medical Center; 🇺🇸 Dallas, Texas, United States

Davita Clinical Research - El Paso; 🇺🇸 El Paso, Texas, United States

Cook Children's Medical Center; 🇺🇸 Fort Worth, Texas, United States

Prolato Clinical Research Center; 🇺🇸 Houston, Texas, United States

Ronald Ralph MD PA; 🇺🇸 Houston, Texas, United States

Houston Medical Research Institute, LLC; 🇺🇸 Houston, Texas, United States

Clinical Research Strategies - Romano North Main Office; 🇺🇸 Houston, Texas, United States

Southwest Houston Research, Ltd; 🇺🇸 Houston, Texas, United States

North Texas Kidney Disease Associates; 🇺🇸 Lewisville, Texas, United States

Prime Clinical Research Inc - Lewisville; 🇺🇸 Lewisville, Texas, United States

Texas Tech University Health Sciences Center; 🇺🇸 Lubbock, Texas, United States

Prime Clinical Research; 🇺🇸 Mansfield, Texas, United States

San Antonio Kidney; 🇺🇸 San Antonio, Texas, United States

University of Texas Health San Antonio; 🇺🇸 San Antonio, Texas, United States

Kidney Specialists of N Houston, PLLC; 🇺🇸 Shenandoah, Texas, United States

Renal Physicians of Montgomery County, PA; 🇺🇸 The Woodlands, Texas, United States

Tranquil Clinical Research; 🇺🇸 Webster, Texas, United States

University of Virginia Health - Nephrology Clinical Research Center; 🇺🇸 Charlottesville, Virginia, United States

TKS Research, P.L.L.C.; 🇺🇸 Norfolk, Virginia, United States

York Clinical Research, LLC; 🇺🇸 Norfolk, Virginia, United States

Richmond VAMC; 🇺🇸 Richmond, Virginia, United States

Virginia Commonwealth University - Division of Nephrology; 🇺🇸 Richmond, Virginia, United States

Nephrology Associates of Tidewater, LTD; 🇺🇸 Virginia Beach, Virginia, United States

University of Washington Medical Center; 🇺🇸 Seattle, Washington, United States

Medical College of Wisconsin; 🇺🇸 Milwaukee, Wisconsin, United States

Milwaukee Nephrologists - Wauwatosa; 🇺🇸 Wauwatosa, Wisconsin, United States

Cliniques Universitaires Saint-Luc; 🇧🇪 Woluwe-Saint-Lambert, Brussels, Belgium

Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg; 🇧🇪 Leuven, Belgium

Centro de Pesquisa Clinica do Coracao; 🇧🇷 Aracaju, Brazil

Santa Casa de Misericórdia de Belo Horizonte; 🇧🇷 Belo Horizonte, Brazil

Upeclin - UNESP Botucatu - CKD and Hypertension Department; 🇧🇷 Botucatu, Brazil

Upeclin - UNESP Botucatu - Kidney Transplantation Department; 🇧🇷 Botucatu, Brazil

IPECC - Instituto de Pesquisa Clinica de Campinas; 🇧🇷 Campinas, Brazil

Hospital Universitário Valter Cantídio; 🇧🇷 Fortaleza, Brazil

Instituto de Ensino e Pesquisa Clinica do Ceara; 🇧🇷 Fortaleza, Brazil

Federal University of Goiás (UFG); 🇧🇷 Goiania, Brazil

Cmip-Centro Mineiro de Pesquisa Ltda; 🇧🇷 Juiz de Fora, Brazil

Galileo Medical Research Ltda; 🇧🇷 Juiz De Fora, Brazil

ICM - Instituto do Coracao de Marilia; 🇧🇷 Marilia, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre; 🇧🇷 Porto Alegre, Brazil

UFRS - Hospital de Clínicas; 🇧🇷 Porto Alegre, Brazil

Centro de Pesquisa Clinica Professor Salomao Kelner; 🇧🇷 Recife, Brazil

Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo; 🇧🇷 Ribeirao Preto, Brazil

Hospital São Lucas; 🇧🇷 Rio de Janeiro, Brazil

Hospital Universitário Pedro Ernesto; 🇧🇷 Rio de Janeiro, Brazil

Pedro Ernesto University Hospital; 🇧🇷 Rio de Janeiro, Brazil

CSB Group of Nephrology Brazil; 🇧🇷 Salvador, Brazil

Irmandade Da Santa Casa De Misericordia De Sao Paulo; 🇧🇷 Sao Paulo, Brazil

Fundação Faculdade Regional de Medicina de São José do Rio Preto; 🇧🇷 São José do Rio Preto, Brazil

Hospital do Rim - Fundação Oswaldo Ramos - Ambulatorio NEFRITE; 🇧🇷 São Paulo, Brazil

University of Sao Paulo; 🇧🇷 São Paulo, Brazil

Recherche GCP Research; 🇨🇦 Montreal, Canada

Women's College Hospital; 🇨🇦 Toronto, Canada

Clinica de La Costa S.A.S; 🇨🇴 Atlántico, Colombia

Solano & Terront Servicios Medicos SAS - Unidad Integral de Endocrinologia - UNIENDO; 🇨🇴 Bogota, Colombia

Fundación Valle Del Lili; 🇨🇴 Cali, Colombia

Centro Cardiovascular Aristides Sotomayor Santa Lucía SAS IPS; 🇨🇴 Cartagena, Colombia

Mediservis del Tolima IPS S.A.S.; 🇨🇴 Ibague, Colombia

Promotora Medica Las Americas S.A. - Clinica Las Americas; 🇨🇴 Medellin, Colombia

Fundación Hospitalaria San Vicente de Paul; 🇨🇴 Medellín, Colombia

Hopital Henri Mondor; 🇫🇷 Créteil, France

CHU Grenoble Alpes - Hôpital Nord Michallon; 🇫🇷 Grenoble, France

Hôpital Bicêtre AP-HP; 🇫🇷 Le Kremlin Bicêtre, France

CHU Dupuytren 2; 🇫🇷 Limoges, France

Hôpital de la Conception, Centre de néphrologie et transplantation rénale; 🇫🇷 Marseille, France

Ambroise Paré Hospital; 🇫🇷 Paris, France

Hopitaux Universitaires Est Parisien - Hopital Tenon; 🇫🇷 Paris, France

Service de Nephrologie - Hopital Universitaire Necker; 🇫🇷 Paris, France

Université Paris-Descartes / Hôpital Européen Georges Pompidou; 🇫🇷 Paris, France

CHU de Guadeloupe; 🇫🇷 Pointe-à-Pitre Cedex, France

AURA Nord Saint Ouen; 🇫🇷 Saint-Ouen, France

Centre Hospitalier Universitaire CHU de Toulouse Hopital de Rangueil; 🇫🇷 Toulouse, France

University of Ghana Medical School; 🇬🇭 Accra, Ghana

The Bank Hospital; 🇬🇭 Cantonments, Ghana

Komfo Anokye Teaching Hospital; 🇬🇭 Kumasi, Ghana

University of Amsterdam; 🇳🇱 Amsterdam, Netherlands

University of Nigeria Teaching Hospital; 🇳🇬 Enugu, Nigeria

University College Hospital; 🇳🇬 Ibadan, Nigeria

Lagos University Teaching Hospital; 🇳🇬 Idi-Araba, Nigeria

Lagos State University Teaching Hospital; 🇳🇬 Ikeja, Nigeria

Nigerian Institute of Medical Research; 🇳🇬 Yaba, Nigeria

Unidade Autónoma de Nefrologia; 🇵🇹 Amadora, Portugal

Department of Nephrology and Renal Transplant; 🇵🇹 Lisboa, Portugal

Hospital Curry Cabral; 🇵🇹 Lisboa, Portugal

Hospital Beatriz Angelo; 🇵🇹 Loures, Portugal

FDI Clinical Research; 🇵🇷 Mayaguez, Puerto Rico

Alliance, School of Medicine; 🇵🇷 Rio Piedras, Puerto Rico

GCM Medical Group, PSC; 🇵🇷 San Juan, Puerto Rico

Hospital Clinic de Barcelona; 🇪🇸 Barcelona, Spain

Hospital Universitari Vall d'Hebron; 🇪🇸 Barcelona, Spain

Reina Sofia University Hospital; 🇪🇸 Córdoba, Spain

Hospital Universitario 12 de Octubre; 🇪🇸 Madrid, Spain

Hospital Universitario Virgen Macarena; 🇪🇸 Seville, Spain

Basildon University Hospital Renal Department; 🇬🇧 Basildon, United Kingdom

AES Glasgow (DRS); 🇬🇧 Bellshill, United Kingdom

AES Midlands (DRS); 🇬🇧 Birmingham, United Kingdom

FutureMeds Birmingham; 🇬🇧 Birmingham, United Kingdom

University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital; 🇬🇧 Birmingham, United Kingdom

Epsom and St Helier University Hospitals NHS Trust - St Helier Hospital - South West SW Thames Institute for Renal Research; 🇬🇧 Carshalton, United Kingdom

University Hospitals of Leicester NHS Trust - Leicester General Hospital; 🇬🇧 Leicester, United Kingdom

Barts Health NHS Trust, The Royal London Hospital; 🇬🇧 London, United Kingdom

Great Ormond Street Hospital for Children; 🇬🇧 London, United Kingdom

Guy's & St Thomas NHS Foundation Trust, Guy's Hospital; 🇬🇧 London, United Kingdom

King's College Hospital; 🇬🇧 London, United Kingdom

Royal Free NHS Trust; 🇬🇧 London, United Kingdom

St George's University Hospitals NHS Foundation Trust; 🇬🇧 London, United Kingdom

St Pancras Clinical Research; 🇬🇧 London, United Kingdom

AES NW Consortium Manchester (DRS); 🇬🇧 Manchester, United Kingdom

Manchester Royal Infirmary; 🇬🇧 Manchester, United Kingdom

The Medicines Evaluation Unit; 🇬🇧 Manchester, United Kingdom

Nottingham University Hospitals NHS Trust, Children's Clinical Research Facility; 🇬🇧 Nottingham, United Kingdom