The Impact of Acipimox and Salbutamol Supplementation on the Development of Insulin Resistance and Anabolic Resistance During Forearm Immobilization in Healthy, Young Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 1
- 主要终点
- Percent Change in Forearm Glucose Uptake
研究概览
简要总结
The present study will investigate the impact of altered substrate availability on muscle atrophy, insulin sensitivity and muscle protein synthesis following short-term forearm immobilization
详细描述
Thirty-six healthy young volunteers will undergo 2 days of forearm immobilization combined with ingestion of one of two drug or placebo. Before and after immobilization, they will receive a stable isotope tracer infusion (5.5 h) combined with repeated blood and muscle sampling under insulin clamp conditions, in order to measure insulin sensitivity and muscle protein synthesis in the fasted and fed state.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Double-blind study design
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males and females 18-40 years of age
- •Body mass index between 18 and 27
排除标准
- •Any diagnosed metabolic impairment (e.g. type 1 or 2 diabetes)
- •Any diagnosed cardiovascular disease
- •Hypertension (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- •Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- •Regular use of nutritional supplements
- •Metallic implants
- •A personal or family history of thrombosis, epilepsy, seizures or schizophrenia
- •Any previous motor disorders
- •Any known disorders in lipid metabolism
- •Any known disorders in muscle metabolism
- •Known allergy for Acipimox, beta agonist, or other substances in the tablets
- •Known sensitivity for sympathomimetic drugs
- •Known hypokalaemia
- •Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- •Known severe kidney problems
- •Pregnancy
- •Unable to give consent
结局指标
主要结局
Percent Change in Forearm Glucose Uptake
时间窗: During the steady-state phase of the insulin clamp (i.e. last 30 min)
Insulin sensitivity, measured as forearm glucose uptake, during a 30-min baseline period and hyperinsulinaemic-euglycaemic conditions
次要结局
- Percent Change in Muscle Protein Synthesis(In the fasted state (30 min before starting insulin clamp), and during the steady-state phase of the insulin clamp (i.e. last 30 min))