Improved Quality of ANC and Diagnostic Services for Malaria in Pregnancy
Overview
- Phase
- Phase 4
- Intervention
- ASAQ
- Conditions
- Malaria
- Sponsor
- Centre Muraz
- Enrollment
- 5254
- Locations
- 1
- Primary Endpoint
- Placental malaria at delivery
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The program's overall objective is to assess the impact of a package of interventions aimed at reducing malaria-related mortality and morbidity in pregnant women and newborns by ensuring access to a package of interventions designed to optimise the detection and treatment of malaria during pregnancy as well as improving the early detection and treatment of malaria during the third trimester.
Detailed Description
This is a cluster-randomised study in which the health facility is the unit of randomisation. 16 health facilities will be randomised to intervention and control. At the community level women will be encouraged to access ANC early in the pregnancy, attend follow-up antenatal visits throughout the pregnancy and deliver at the facility. The current recommended standard of care will be provided to all women attending antenatal and obstetric care. In the intervention area, obstetric, medical, drug-exposure histories will be collected at ANC visits. In addition, in the last trimester of the pregnancy (\> 28 weeks of pregnancy), women will be systematically evaluated with selected diagnostic test for whether they have malaria parasites and treated effectively. Skilled birth attendants at the facility will be trained in emergency obstetric and neonatal care and the assessment of neonates for danger signs, low birth weight and external/observable birth defects. In the control area, women will be provided with standard practice of care. In both areas, women will be diagnosed and treated at delivery if they are positive.
Investigators
Tinto Halidou
PharmD, Msc, PhD
Centre Muraz
Eligibility Criteria
Inclusion Criteria
- •Located in the geographical location of Dafra \& Do district
- •Have a minimum attendance of 200 pregnant women per year
Exclusion Criteria
- •other public health facilities, private clinics and Dafra District Hospital will be excluded from the study.
Arms & Interventions
ASAQ
In the intervention area, obstetric, medical, drug-exposure histories will be collected at ANC visits. In addition, in the last trimester of the pregnancy women will be systematically evaluated with RDT for whether they have malaria parasites and treated effectively.
Intervention: ASAQ
Outcomes
Primary Outcomes
Placental malaria at delivery
Time Frame: 9 months
The main outcome variable of interest will be the proportion of women in each group with placental malaria at delivery (defined as placental biopsies positive for P. falciparum )
Secondary Outcomes
- The proportion of women with peripheral positive malaria infection at delivery(9 months)