Multicenter Intervention Program to Optimize the Clinical Management of Community-acquired Pneumonia in Hospitals

• Conditions: Community Acquired Pneumonia

• Registration Number: NCT02224716
• Lead Sponsor: Fundación Pública Andaluza Progreso y Salud

Brief Summary

The purpose of this study is to evaluate the impact of a structured package (bundle) in reducing the use of antimicrobials and hospital stay of patients with community-acquired pneumonia (CAP), and no increase in mortality of these patients in different hospitals.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-07
• Study First Submitted: 2014-08-22
• Study First Submitted QC: 2014-08-22
• Study First Posted: 2014-08-25
• Status Verified: 2015-06
• Last Update Submitted: 2015-06-11
• Last Update Posted: 2015-06-12
• Primary Completion: 2015-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 968

Inclusion Criteria

• Diagnosis of CAP at hospital admission .
• Age: 18 years or more.

Exclusion Criteria

• Patients with nosocomial pneumonia or criteria related to health care.
• Patients with severe immunosuppression (HIV infection with <200 CD4+ lymphocytes / mm3), neutropenia (<500 neutrophils / mm3).
• Patient treated with immunosuppressive drugs.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Antimicrobial use in patients hospitalized for CAP.	twelve months	It is measured in defined daily doses (DDD) per 100 hospital stay of patients hospitalized with CAP.
Mortality rate to 30 days	twelve months	Number of death of patients hospitalized with CAP, stratified by CURB-65 score.

Secondary Outcome Measures

Name	Time	Method
Specific antimicrobial treatment	Twelve months	Implementation of quality indicators in the management of CAP. They are expressed as dichotomous variables (yes / no): Number of doctors who prescribed the specific antimicrobial treatment defined in the guideline
Total duration of antibiotic therapy.	Twelve months	Implementation of quality indicators in the management of CAP. They are expressed as dichotomous variables (yes / no): Number of doctors who prescribe an antimicrobial treatment during 7 days or less, or 5 days or less after clinical improvement.
CAP severity CURB-65 or PSI registered.	twelve months	Implementation of quality indicators in the management of CAP. They are expressed as dichotomous variables (yes / no): Numbers of doctors who register on the clinical history the evaluation of CAP severity by CURB-65 or PSI at hospitalization.
Microbiological samples at admission.	twelve months	Implementation of quality indicators in the management of CAP. They are expressed as dichotomous variables (yes / no): Numbers of doctors who taking all microbiological samples recommended in the guideline in the first 6 hours of patient admission.
Appropriate supportive treatment	Twelve months	Implementation of quality indicators in the management of CAP. They are expressed as dichotomous variables (yes / no): Number of doctors who take supportive treatment according to guideline during the hospitalization.
Empirical treatment	Twelve months	Implementation of quality indicators in the management of CAP. They are expressed as dichotomous variables (yes / no): Number of doctors who prescribed empirical treatment according to the guideline at admission.
Appropriate sequential therapy.	Twelve months	Implementation of quality indicators in the management of CAP. They are expressed as dichotomous variables (yes / no): Number of doctors who switch to oral therapy according to guideline.

Trial Locations

Locations (1)

Fundación Pública Progreso y Salud; 🇪🇸 Sevilla, Spain