octurnal free fatty acids. Measurements in obese and lean subjects and the effect of beta-blockage on pulsatile release.
- Conditions
- 10018424insulin resistance
- Registration Number
- NL-OMON32829
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Kaukasische man met een BMI > 30 kg/m2 of een BMI 20<25 kg.m2.
Exclusion Criteria
* any chronic medical condition or use of any medication
* asthma and bronchospastic COPD
* tobacco use
* alcohol abuse (>3/day)
* frequent intensive exercise (>2 week)
* familial lipid disorders, renal insufficiency (creatinine > 150 umol/L) , elevated liver enzymes (> 2 times), hypertension
* Hypotension (BP < 100/60 mmHg), bradycardia (HR < 60min)
* unwilling or unable to provide informed consent
* first degree family members with diabetes
* abnormal day/night rhythm (shiftworkers etc)
* Blood donation in the past three months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Percent and/or absolute changes in nocturnal FFA levels with or without *-<br /><br>blockage.<br /><br>2. Difference in nocturnal FFA levels between lean and obese subjects.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Phenotypical differences (adipose tissue distribution, plasma parameters)</p><br>