The Acute Effects of Food Structure on Post Prandial Glucose and Subsequent Metabolic Responses
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 主要终点
- Post-prandial Blood Insulin Concentrations
研究概览
简要总结
Aims: To investigate the effects of different food structures on glucose concentrations and subsequent metabolic responses including insulin,GIP, GLP-1 DESIGN: A randomised, controlled, clinical trial.
详细描述
Rationale:
There is very little evidence at the present time in the role of food structure in glucose homeostasis. There is circumstantial evidence that foods consumed intact have great effects on suppressing appetite.
To test the effect of three structurally different meals with the same nutritional content and volume on appetite regulation. Each participant will receive the following meals:
Solid meal group. Milled (intact-cell) meal group. Milled (destroyed-cell) meal group.
All of which will contain the same macro and micro nutrients from the same food sources
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Gender: male and female
- •Age ≥ 18 years ≤ 65 years
- •Normal weight as classified by BMI 20-29.9 kg/m2
- •Healthy, not diagnosed with any chronic diseases assessed as appropriate for inclusion, based on the pre-study screening.
- •Willingness and ability to understand, participate and to comply with the study requirements
- •Willingness and ability to give written informed consent
排除标准
- •Has thyroid defects
- •Under hormone or steroids therapy
- •Is pregnant or lactating (female)
- •Had given birth within the past year (female)
- •Is taking drugs that could affect appetite or plasma glucose levels.
- •Is taking natural remedies that modulate appetite or plasma glucose levels.
- •Has excessive alcohol intake
- •Had blood donation within 12wks prior to start date
- •Psychiatric illness
- •History of any disease with unknown outcome
- •Has diabetes
- •Has nut allergy
结局指标
主要结局
Post-prandial Blood Insulin Concentrations
时间窗: before the consumption of the test meal and then 15, 30, 60, 90, 120, and 180 minutes post consumption of test meal.
Blood glucose concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus. Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal.
Post-prandial Glucose Concentrations
时间窗: before the consumption of the test meal and then 15 min, 30, 60,90, 120, 180 minutes after the consumption of the test meal.
Blood glucose concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus. Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal. Data were not collected for intact cell chickpea hummus
次要结局
- Post-prandial Gut Hormone Glucagon-like Peptide 1 (GLP-1)(baseline before the consumption of the test meal, and then 15,30,60,90,120,180 min after the consumption of the test meal.)
- Post-prandial Gut Hormone Gastric Inhibitory Polypeptide (GIP)(before the consumption of the test meal at 0 min and then post test meal at 15, 30,60 ,90,120 and 180 minutes.)
- Energy Intake at a Meal Given in Excess(post consumption of the test meal at 120 minutes)