Food Orders on Blood Glucose and Fuel Use At Rest

Not Applicable

Recruiting

• Conditions: Glucose Metabolism Disorders; Hunger; Fat Burn

• Registration Number: NCT06763562
• Lead Sponsor: Old Dominion University

Brief Summary

Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. However, gaps remain in the literature in this area of research, and currently little is known about how substrate (fuel) use is impacted by altering food order. In addition, most studies to date have used a mix of meat and plant foods, while little research has focused exclusively on vegetarian foods. This randomized experiment will examine how altering the order of foods eaten in a vegetarian meal impacts blood glucose and fuel utilization at rest.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-01
• Study First Submitted: 2025-01-02
• Study First Submitted QC: 2025-01-02
• Study Start: 2025-01-05
• Study First Posted: 2025-01-08
• Last Update Submitted: 2025-02-16
• Last Update Posted: 2025-02-19
• Primary Completion: 2026-06-30
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 18-70 years old
• Free from any allergy or condition that precluding consumption of edamame, butter, and rice
• Not currently pregnant
• Free of any medical conditions requiring the use of insulin
• Have no history of bariatric surgery
• Have no implanted electrical devices such as a pacemaker

Exclusion Criteria

• Younger than 18 and older than 70 years old
• Having an allergy or condition that precludes consumption of edamame, butter, and rice
• Currently pregnant
• Any medical conditions requiring the use of insulin
• A history of bariatric surgery
• Having an implanted electrical device such as a pacemaker

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Respiratory exchange ratio	90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)	Ratio of carbon dioxide production and oxygen consumption for determination of fuel use

Secondary Outcome Measures

Name	Time	Method
Fat use	90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)	Fat utilization will be estimated from respiratory gas exchange
Carbohydrate use	90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)	Carbohydrate utilization will be estimated from respiratory gas exchange
Blood glucose	90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)	Blood glucose will be measured with fingerstick samples and a portable glucometer
Hunger-satiety perceptions	90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)	Hunger, appetite, satiety, and fullness on a 0-10 Likert scale

Trial Locations

Locations (1)

Old Dominion University Human Performance Laboratory; 🇺🇸 Norfolk, Virginia, United States