Imminently Effect of Interval Training With High Intensity (HIT) After Heart Transplantation
- Conditions
- Heart Transplantation
- Interventions
- Other: interval trainingOther: moderate exercise
- Registration Number
- NCT02602834
- Lead Sponsor
- Oslo University Hospital
- Brief Summary
High intensity Interval training (HIT) has repeatedly been documented to have superior positive effects on oxygen uptake and general physical health compared to continuous moderate exercise in healthy individuals and patients with heart disease. Recently, the same effect has been shown in heart transplanted recipients. Which mechanisms that explains this difference is uncertain; the effect can be due to changes in the heart or changes in the peripheral tissue and muscles. To explore these mechanisms the investigators will in this study compare two different exercise modalities, and explore how different biomarkers change in blood, related to exercise.
- Detailed Description
15 heart transplanted recipients (and 5 healthy controls) will be included in the study. Each patient will have three study-days.
The study is designed to be a cross-over study. And randomisation will decide which training they will have som training session 1 and training session 2; Interval or continuous training.
Before starting the two training sessions they will measure oxygen uptake and baseline blood samples.
During each exercise session the patients will take blood samples during and after exercise.
After first study admission the patients will have a wash out period for 1 week until first training session, and another week until the last session.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 19
Not provided
- Under 1 year or over 10 year since HTx.
- Lives far from Oslo
- Unstable health condition
- Not optimal medical treatment and/ or medication
- Limiting physical handicap
- Under 18 years
- Not written consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description HTx interval training Heart transplant recipients n=15 HTx moderate exercise Heart transplant recipients n=15 Control moderate exercise Healthy controls n=5 Control interval training Healthy controls n=5
- Primary Outcome Measures
Name Time Method Changes in interleukin levels with interval training compared to moderate training 1 week Changes in ICAM levels with interval training compared to moderate training 1 week Changes in crp with interval training compared to moderate training 1 week Changes in MiRNA levels with interval training compared to moderate training 1 week
- Secondary Outcome Measures
Name Time Method Questionnaire of physical activity baseline Questionnaire of quality of life baseline Oxygen uptake baseline V02 peak measured på exercise test on treadmill.
Trial Locations
- Locations (1)
OUS- Rikshospitalet
🇳🇴Oslo, Norway