The evaluation of the potential damage to vascular wall in the perioperative settings during periods of dehydration and following infusion of cristalloid solutions during general anaesthesia

Not Applicable

Completed

• Conditions: Perioperative fluid management; Surgery

• Registration Number: ISRCTN81005631
• Lead Sponsor: Pauls Stradinš Clinical University Hospital

Brief Summary

2017 results in https://pubmed.ncbi.nlm.nih.gov/28830365/ (added 30/11/2020) 2020 results in https://pubmed.ncbi.nlm.nih.gov/32334513/ (added 30/11/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-06-10
• Study Completion: 2018-06-30
• Last Update Posted: 5 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1. Patients scheduled for elective laparotomy under general anesthesia
2. Aged between 20 and 55
3. ASA I-II

Exclusion Criteria

1. Urgent surgery patients
2. ASA III-IV
3. Refusal to participate
4. Pregnancy
5. Those undergoing operations under spinal or epidural anaesthesia
6. Blood loss more than 500 ml
7. Acute or chronic kidney disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain natriuretic peptide (BNP) levels in plasma and urine after rapid fluid infusion are measured using chemiluminescent microparticle immunoassay (CMIA) at baseline (immediately before anaesthesia), immediately after anaesthesia induction, at 30 minute intervals throughout anaesthesia, and two hours after anaesthesia.