Epigenetic mechanisms linking a mothers’ nutrition to the health of her children in India and Sub-Saharan Africa

Not Applicable

Completed

• Conditions: DNA methylation, growth, body composition, neuro-development, cardio-metabolic risk, bone health; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN14266771
• Lead Sponsor: niversity of Southampton

Brief Summary

2017 Protocol article in https://pubmed.ncbi.nlm.nih.gov/30820326/ protocol (added 30/06/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32889533/ results (added 08/09/2020) 2022 Results article in https://doi.org/10.1186/s13148-021-01213-3 (added 15/06/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-18
• Study Completion: 2020-05-28
• Last Update Posted: 26 June 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 293

Inclusion Criteria

1. Healthy children aged five to seven years participating in the SARAS KIDS study (2013-2018) who were born as singleton live births to mothers who took part before and during pregnancy in the Mumbai Maternal Nutrition Project in India (http://www.isrctn.com/ISRCTN62811278) and who started supplementation at least 3 months prior to conception
2. Healthy children aged five to seven years in the Gambia who were born as singleton live births to mothers who took part in the Peri-conceptional Multiple Micronutrient Supplementation Trial (http://www.isrctn.com/ISRCTN13687662) in the Gambia
3. Parents consented to their participation in follow-up studies in which size, body composition, cardio-metabolic risk markers, cognitive function, and bone health were measured
4. Consented to the use of their DNA samples for this research
5. Samples contained sufficient DNA

Exclusion Criteria

Children whose mothers took part in the Mumbai trial but who did not start supplementation at least 3 months before conception.

Study & Design

• Study Type: Observational
• Study Design: Not specified