LSFG-SKIN, Laser Speckle Flowgraphy

Not Applicable

Terminated

• Conditions: Radiation Injuries; Vascular Ischemia; Burns; Multiple Sclerosis; Chemotherapy Effect; Uveitis; Scleritis; Stroke; Intracranial Hemorrhages; TIA
• Interventions: Device: laser speckle flowgraphy

• Registration Number: NCT03660618
• Lead Sponsor: Randy Kardon

Brief Summary

The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or environmental changes, such as temperature, light and pressure.

Detailed Description

Laser speckle skin blood flow (LSFG-SKIN) will be recorded in normal subjects and in patients with disorders affecting skin capillary perfusion, which may include cardiovascular disorders, dermatologic disorders, skin wounds, ocular disorders, psychiatric disorders, and neurologic disorders.

Study Timeline

• Study Start: 2017-05-23
• Study First Submitted: 2018-07-12
• Study First Submitted QC: 2018-09-04
• Study First Posted: 2018-09-06
• Primary Completion: 2019-03-02
• Study Completion: 2019-03-02
• Results First Submitted: 2019-05-07
• Status Verified: 2023-05
• Results First Submitted QC: 2023-05-09
• Last Update Submitted: 2023-05-09
• Results First Posted: 2023-05-10
• Last Update Posted: 2023-05-10

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

Controls

●Healthy normal control subjects ages 18-90

Cardiology Subjects

• Ages 18-90
• History of dysrhythmia, heart failure, cardiac ischemia, hypertension, peripheral vascular disease

Dermatology Subjects

• Ages 18-90
• History of inflammatory and cancerous lesions

Endocrine Subjects

• Ages 18-90
• History of diabetes, thyroid disease

Neurology Subjects

• Ages 18-90
• History of dementia, headaches, Parkinson's, light sensitivity, stroke, TIA, multiple sclerosis

Psychiatry Subjects

• Ages 18-90
• History of bipolar, schizophrenia, anxiety, depression

Surgery Subjects

• Ages 18-90
• History of skin wounds(trauma, chemotherapy, radiation), thermal burns, or plastic and reconstructive surgical procedures.

Ophthalmology Subjects

• Ages 18-90
• History of ocular disorders caused by hypo perfusion or inflammatory disorders

Exclusion Criteria

Controls

• Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
• Angle closure glaucoma

Cardiology Subjects

• Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.

• Angle closure glaucoma

  3. Dermatology Subjects

• Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.

• Angle closure glaucoma

Endocrine Subjects

• Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
• Angle closure glaucoma

Neurology Subjects

• Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
• Angle closure glaucoma

Psychiatry Subjects

• Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
• Angle closure glaucoma

Surgery Subjects

• Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
• Angle closure glaucoma

Ophthalmology Subjects

• Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
• Angle closure glaucoma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Clinic Subjects	laser speckle flowgraphy	cardiology subjects, dermatology subjects, endocrine subjects, neurology subjects, psychiatry subjects, surgery subjects, ophthalmology subjects.

Primary Outcome Measures

Name	Time	Method
Imaging Blood Flow	One visit	Imaging blood flow in the tissue is of major importance in the clinical environment

Trial Locations

Locations (1)

University of Iowa Department of Ophthalmology; 🇺🇸 Iowa City, Iowa, United States