The effect of functional training with audible-cues on cortico-motor excitability and motor unit behavior in athletes with chronic ankle instability

Phase 2

Recruiting

• Conditions: Athletes with chronic ankle instability especially in jump and landing sports (basketball, volleyball, and football) who fully returned to sport.; Chronic ankle instability; Ankle sprain; Athletes; Rehabilitation

• Registration Number: TCTR20230412001
• Lead Sponsor: Research management and development Division, Office of the President, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-04-12
• Last Update Posted: 19 August 2024
• Study Completion: 2025-01-31

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

Basketball, volleyball, and football players in university level, age 18-25 years old and BMI in range of 18-25 kg/m2 who have history of CAI will be included in this study. The classification for CAI will be by ankle injury history questionnaire and the 30-point Cumberland ankle instability tool (CAIT). The CAI participants had a history of significant lateral ankle sprain at dominant side (at least once) more than 1 year of initial sprain (41), feeling of giving away in ankle in the 6 months before study at least 1 time (42), and a CAIT score less than and equal to 25 (43). Moreover, CAI individuals will demonstrate negative anterior drawer test and talar tilt test of ankle joint for excluding mechanical instability of ankle.

Exclusion Criteria

1. History of musculoskeletal problem such as joint pain or muscle pain of lower extremities within 3 months before study.
2. History of serious injury or operation of lower extremities such as ACL reconstruction, fracture of femur, or ankle fracture.
3. History of low back pain in 6 months before the study by receiving medication or physical therapy.
4. History of taking medication or agent related to change of muscle properties such as muscle relaxant within 24 hours before testing.
5. Participants who can't pass the safety screening for TMS machine.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak to peak motor evoked potential, resting motor threshold, and latency of peroneus longus, tibialis anterior, and medial gastrocnemius muscles pre-intervention, post-intervention, 3 months post-intervention, 6 months post-intervention. transcranial magnetic stimulation,Motor unit firing rate and peak motor unit firing rate of tibialis anterior, and medial gastrocnemius muscles pre-intervention, post-intervention, 3 months post-intervention, 6 months post-intervention. decomposition electromyography,Angles and moments of hip, knee, and ankle joints during initial contact and peak ground reaction force phases in 3 planes. pre-intervention, post-intervention, 3 months post-intervention, 6 months post-intervention. Motion analysis,Peak ground reaction force and ground reaction force at initial contact pre-intervention, post-intervention, 3 months post-intervention, 6 months post-intervention Motion analysis

Secondary Outcome Measures

Name	Time	Method
The foot and ankle ability measure (FAAM) pre-intervention, post-intervention, 3 months post-intervention, 6 months post-intervention The foot and ankle ability measure (FAAM)