PET study using [11C]K-2 on the relationship between AMPA receptor and tau accumulation in Alzheimer's disease and related diseases

Not Applicable

Recruiting

• Conditions: Alzheimer' s disease,Mild cognitive impairment(MCI)

• Registration Number: JPRN-UMIN000046956
• Lead Sponsor: Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-03-01
• Last Update Posted: 17 October 2023
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

Patients diagnosed with MCI or AD 1) Patients with a history of or complications from organic brain disease (disorders of consciousness, head trauma requiring hospitalization, obvious cerebral infarction or cerebral hemorrhage, etc.) (2) Those who have substance-related disorders (e.g., drug dependence). (3) Those who have complications from serious diseases, or those who have a history of such complications and are judged by the physician as the researcher to be inappropriate for this research. (4) Those with pacemakers or internal metal devices (brain clips, bolts, etc.) (5) Those with tattoos (including tattoos and art makeup) (6) Those who are highly claustrophobic (7) Patients who are pregnant or may be pregnant, and those who are breastfeeding (8) Others who are judged inappropriate as research subjects by the researcher's physician. Healthy volunteer group 1) Subjects with a history of or complications from organic brain disease (disorders of consciousness, head trauma requiring hospitalization, obvious cerebral infarction or cerebral hemorrhage, etc.) (2) Those who have substance-related disorders (e.g., drug dependence). (3) Those who have complications from serious diseases, or those who have a history of such complications and are judged by the physician as the researcher to be inappropriate for this research. (4) Those with pacemakers or internal metal devices (brain clips, bolts, etc.) (5) Those with tattoos (including tattoos and art makeup) (6) Those who are highly claustrophobic (7) Patients who are pregnant or may be pregnant, and those who are breastfeeding (8) Subjects who are judged inappropriate as research subjects by the researcher's physician.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantitative evaluation of the distribution of [11C]K-2