A clinical trial to examine age-and-sex-related changes of AMPA receptor density in healthy volunteers.

Not Applicable

Recruiting

• Conditions: Healthy volunteers

• Registration Number: JPRN-jRCTs031200083
• Lead Sponsor: Abe Hiroki

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-08-12
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

We will target healthy volunteers who meet all the following conditions.
1.Males and females between 20 and 70 years old at the time of obtaining informed consent.
2.No history of mental or neurological disease.
3.Sufficient consent judgment ability of the person in the evaluation by MacCAT.
4.No current mental disorders without meeting any criteria in SCID-I /DSM-IV,DSM-5, ICD-10.

Exclusion Criteria

1. Person with psychotropic drugs, antidepressant, hypnotic, anxiolytic, antipsychotic.
2. Pregnant, lactating female.
3. Hypersensitive to ethanol.
4. neurolog ical disease (neurodegenerative disease, minor cerebral hemorrhage or cerebral infarction)
5. History of malignant brain tumor
6. History of epilepsy
7. Under medical treatment for other diseases
8. Substance-related disorders within 6 months except for nicotine and caffeine
9. Positive urine recreational drug screening (excluding person who takes the drugs for medication purposes)
10. Pacemaker or any metal devices in the body
11. Head, neck and body size are not suitable for MRI scanner
12. Big tattoo and art makeup on their skin
13. Severe claustrophobia
14. Congenital or traumatic brain abnormalities
15.Any of the following abnormal laboratory test values
Serum creatinine 1.5mg / dl or more
AST 150IU/L or more
ALT 150IU/L or more
16. Person who have taken [11C] K-2 PET in other clinical trials.
17. Participants with unapproved nuclear medicine tests or clinical trials within 6 months before registration
18. Participants of other clinical trials or clinical trials within 12 weeks prior to enrollment (limited to those with invasion/intervention)
19. other reasons by the investigator

Study & Design

• Study Type: Interventional
• Study Design: Not specified