Investigating the Effects of Timed Exercise on Human Circadian Rhythms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 67
- 试验地点
- 2
- 主要终点
- Change in onset (time) of melatonin secretion
研究概览
简要总结
The purpose of this study was to investigate the effect of timed exercise on human circadian rhythms. Subjects were randomized to 5 days of morning or evening treadmill exercise. A measure of internal circadian timing, or phase, was measured at baseline and following the exercise intervention. Change in circadian phase was compared between the morning and evening group.
详细描述
This study investigated the effect of morning versus evening exercise on internal circadian timing, or phase. Young, sedentary subjects were recruited for this study. Baseline measures included anthropometric, body composition, cardiorespiratory fitness, chronotype, and circadian phase. Subjects were randomized to 5 consecutive days of morning or evening exercise. Thirty minutes of exercise was performed at the designated time and intensity was maintained at a heart rate corresponding with 70% peak VO2. The measure of circadian phase was salivary dim light melatonin onset, indicated by the time when saliva melatonin concentration exceeded 4pg/ml. Post-exercise circadian phase was measured the evening following the last day of exercise. Changes in circadian phase were compared between morning and evening groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 18.5-40.0
- •sedentary; <=2 hrs structured exercise weekly
- •medication free (other than birth control)
排除标准
- •diagnosed conditions that would contraindicate safe participation in physical activity
- •diagnosed psychiatric conditions
- •night or rotating shift work 1-year prior to study
- •travel across time zones within previous 4 weeks
- •having children <2 years of age
研究组 & 干预措施
Morning Exercise Group
Participants perform moderate exercise in the morning.
干预措施: Morning Exercise (Other)
Evening Exercise Group
Participants perform moderate exercise in the evening.
干预措施: Evening Exercise (Other)
结局指标
主要结局
Change in onset (time) of melatonin secretion
时间窗: baseline and following completion of exercise intervention (approximately 5 days)
Difference in onset (time at which salivary melatonin exceeds threshhold; 4pg/mL) from baseline to completion of exercise intervention.
次要结局
未报告次要终点
研究者
Julie Pendergast
Assistant Professor
University of Kentucky