Gastrointestinal and lung cancer, effects of the fish oil intake on nutritional status, quality of life and imunnometabolic outcomes

Not Applicable

Recruiting

• Conditions: Gastric neoplasmsColorectal neoplasmsAnus neoplasmsNon-Small-Cell Lung carcinomaIntestinal neoplasms; C04.588.274.476.411.307; C04.588.894.797.520.109.220.249; C16.9; C04.588.274.476.767; C04.588.274.476.411.307.790.040; C04.588.274.476.411

• Registration Number: RBR-2xcd99
• Lead Sponsor: niversidade Federal de Santa Catarina - UFSC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-03-10
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Individuals with 19 years or older, histopathologic diagnosis of gastric cancer, or colorectal or anal canal or non-small cell lung cancer, ability to start chemotherapy in co-participant institution (CEPON).

Exclusion Criteria

Prior chemotherapy, inability to
oral intake, diagnosis of infectious or inflammatory disease, be allergic to fish and / or derivatives, be pregnant, treatment with statins, ??use of fish oil and/or another supplement containing omega-3 or other polyunsaturated fatty acid in the six months
prior to the study period, continued use of supplements containing antioxidants.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Decrease in levels of inflammatory markers (TH1 response cytokines - IL-2, IL-4, IL-6, TNF, IFN-y, IL-17A, IL-10) and prostaglandin E2 (PGE2), from quantification of the plasma levels of these biomarkers before (baseline), 5 weeks and after (9 weeks) fish oil supplementation, using ELISA technique of quantification, and comparing with levels of control group;Increased activity of antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase) verified through spetophotometric assays in erythrocytes before supplementation and after nine weeks of supplementation with fish oil and comparing with activity of enzymes in control group.