effect of vitamin D treatment on the dry eye parameters in 1394-1395

Phase 2

Conditions: Condition 1: dry eye. Condition 2: Vitamin D deficiency.
Other disorders of lacrimal gland
Vitamin D deficiency
H04.1

Registration Number: IRCT20200615047785N1

Lead Sponsor: Jahrom University of Medical Sciences Vice Chancellor for Research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 50

Inclusion Criteria

Patients referred to the endocrinology clinic of Jahrom University of Medical Sciences with abnormal serum levels of 25OHD

Exclusion Criteria

Patients with SS (Sjogren's Syndrome) or with thyroid disease
Having a history of other systemic rheumatic diseases
Vitamin A deficiency
Glucocorticoid, antidepressant, contraceptive, estrogen
People with vitamin B12 deficiency, eye surface disorders and contact lenses, type 1 diabetes
Pregnancy, lactation
Has a history of eye surgery
Individuals with crp above the baseline

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Eye dry. Timepoint: Measure the dryness of the eye at the beginning of the study (before the intervention) and 8 weeks after taking vitamin D tablets. Method of measurement: Using Schirmer's paper in the lower fornix and measuring its wetting rate, TBUT test result (using fluorescein paper in the lower fornix and measuring the discontinuity time of the lacrimal layer), dry eye score in the OSDI questionnaire.

Secondary Outcome Measures

Name	Time	Method
Serum level 25OHD. Timepoint: At the beginning of the study (before the start of the intervention) and 8 weeks after the intervention. Method of measurement: Blood sampling and blood tests.