Comparison of the Effect of Warfarin and Direct Oral Anticoagulants

Completed

• Conditions: Anticoagulants and Bleeding Disorders; Gastrointestinal Hemorrhage

• Registration Number: NCT06269302
• Lead Sponsor: Samsun Education and Research Hospital

Brief Summary

In this study, it was aimed to compare the frequency of new oral anticoagulants and warfarin usage, and to reveal the rates of recurrent upper gastrointestinal bleeding among patients who applied to our hospital with upper gastrointestinal bleeding

Detailed Description

The data of all patients who applied to Samsun Training and Research Hospital Internal Medicine with a diagnosis of upper gastrointestinal bleeding and hospitalized by Internal Medicine and Gastroenterology clinics or who underwent outpatient endoscopy between 01.01.2021 and 31.12.2021 were included. The patients' data were analyzed from the patient files and hospital automation system retrospectively. Patients who had recurrent upper GI bleeding were detected by controlling them over the hospital software system and by reaching each patient again. The frequency of the new generation oral anticoagulants usage in patients with re-bleeding was determined, and data such as re-bleeding rate, length of hospital stay, need for transfusion, and mortality were analyzed in the groups who did not use this drug and those who used it. The patient demographics were also compared between the groups who were using the new generation oral anticoagulants, acetylsalicylic acid or warfarin.

Study Timeline

• Study Start: 2022-01-01
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Status Verified: 2024-02
• Study First Submitted: 2024-02-12
• Study First Submitted QC: 2024-02-12
• Last Update Submitted: 2024-02-12
• Study First Posted: 2024-02-21
• Last Update Posted: 2024-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 346

Inclusion Criteria

• Age >18 years old
• Upper gastrointestinal bleeding
• 12 months follow-up

Exclusion Criteria

• Age <18 years old
• Lower gastrointestinal bleeding
• Esophageal variceal bleeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in the incidence of recurrent bleeding	12 months	Increase or decrease in the incidence of recurrent bleeding

Trial Locations

Locations (1)

Samsun Education and Research Hospital; 🇹🇷 Samsun, İlkadım, Turkey