Effect of deep neuromuscular block and variations in arterial PCO2 on the surgical rating scale, extubation conditions and postoperative conditions following reversal with sugammadex - BLISS 2

eids Universitair Medisch Centrum0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•(i) Patients diagnosed with renal or prostatic disease who are will undergo an elective
•laparoscopic renal surgical procedure or laparoscopic prostatectomy;
•(ii) ASA class I-III
•(iii) > 18 years of age;
•(iv) Ability to give oral and written informed consent.

•(i) Known or suspected neuromuscular disorders impairing neuromuscular function;
•(ii) Allergies to muscle relaxants, anesthetics or narcotics;
•(iii) A (family) history of malignant hyperthermia;
•(iv) Women who are or may be pregnant or are currently breast feeding;
•(v) Renal insufficiency, as defined by serum creatinine x 2 of normal, or urine output < 0.5
•ml/kg/h for at least 6 h. When available, other indices will be taken into account as well such
•as glomerular filtration rate < 60 ml/h and proteinuria (a ratio of 30 mg albumin to 1 g of
•creatinine).
•(vi) Previous retroperitoneal surgery at the site of the current surgery.
•(vii) Body mass index > 35 kg/m2
•(viii) Chronic obstructive pulmonary disease GOLD 2-4 or a FEV1 less than 70% predicted or VC less than 70% predicted
•(ix) chronic pulmonary disease with altered lung physiology (eg. sarcoidosis, cycstic fibrosis, obstructing pulmonary tumors, previous lung surgery)

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