Bone Mineral Density and Its Associations with Markers of Oxidative Stress in Children and Adolescents with Hemoglobin H with Constant Spring

Research affairs, Faculty of Medicine, Khon Kaen University0 个研究点目标入组 60 人开始时间: 2020年11月8日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Inclusion criteria for the thalassemia group
•1. Ages 10-20 years
•2. Diagnosed with hemoglobin H with Constant Spring (Hb H/CS)
•3. Diagnosed with transfusion-dependent Hb H/CS requiring regular blood transfusion every 4-6 weeks to raise Hb levels >7 g/dL. Generally, patients with 3 out of the following 5 criteria required red blood cell transfusion: 1) anemic symptoms 2) Hb â‰¤7 g/dl 3) growth failure 4) marked hepatosplenomegaly 5) homolytic crisis â‰¥3 episodes/year
•4. Height and weight 10-95%tile
•5. BMI 10-85%tile
•6. Treated and follow up at Khon Kaen University Hospital
•The control group includes age and sex-matched healthy children and adolescents.

•Participants with the following conditions will be excluded:
•1. Diseases or medications affecting bone and vitamin D metabolism except calcium and vitamin D supplement
•2. Pathological fracture
•3. Current or recent fractures (<6 months) or wearing prostheses or instruments around the BMD measurement site
•4. Deformity of the bone at the BMD measurement site
•5. Pregnancy

发起方

Research affairs, Faculty of Medicine, Khon Kaen University