TCTR20201108001
Not yet recruiting
未知
Bone Mineral Density and Its Associations with Markers of Oxidative Stress in Children and Adolescents with Hemoglobin H with Constant Spring
Research affairs, Faculty of Medicine, Khon Kaen University0 sites60 target enrollmentNovember 8, 2020
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Bone mineral density in children and adolescents with transfusion-
- Sponsor
- Research affairs, Faculty of Medicine, Khon Kaen University
- Enrollment
- 60
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Inclusion criteria for the thalassemia group
- •1\. Ages 10\-20 years
- •2\. Diagnosed with hemoglobin H with Constant Spring (Hb H/CS)
- •3\. Diagnosed with transfusion\-dependent Hb H/CS requiring regular blood transfusion every 4\-6 weeks to raise Hb levels \>7 g/dL. Generally, patients with 3 out of the following 5 criteria required red blood cell transfusion: 1\) anemic symptoms 2\) Hb ≤7 g/dl 3\) growth failure 4\) marked hepatosplenomegaly 5\) homolytic crisis ≥3 episodes/year
- •4\. Height and weight 10\-95%tile
- •5\. BMI 10\-85%tile
- •6\. Treated and follow up at Khon Kaen University Hospital
- •The control group includes age and sex\-matched healthy children and adolescents.
Exclusion Criteria
- •Participants with the following conditions will be excluded:
- •1\. Diseases or medications affecting bone and vitamin D metabolism except calcium and vitamin D supplement
- •2\. Pathological fracture
- •3\. Current or recent fractures (\<6 months) or wearing prostheses or instruments around the BMD measurement site
- •4\. Deformity of the bone at the BMD measurement site
- •5\. Pregnancy
Outcomes
Primary Outcomes
Not specified
Similar Trials
Recruiting
Not Applicable
Study of bone mineral density and renal function in cured patients of hyperparathyroidism.CTRI/2019/05/019365Department of Endocrinology
Active, not recruiting
Not Applicable
Effects of different physical activities programs on osteoporosis related-variables in older womeE01.370.600.425Osteopenia, Osteoporosis, postmenopausal womenM81.0N01.400.900G08.686.157.500RBR-6bqsw8niversidade Federal do Estado do Rio de Janeiro (UNIRIO)
Recruiting
Not Applicable
Socket preservation by Bone graft placementCTRI/2023/04/052030Dr Kshipra P Kawadkar
Not yet recruiting
Not Applicable
A study to assess bone mineral density of lumbar spine and hip related to degenerative disease in south KarnatakaCTRI/2021/10/037243Jonsi Johnson
Not yet recruiting
Not Applicable
A study to assess the change of bone mineral in response to increased dietary calcium intake in children.CTRI/2023/05/052693The New York Academy of Sciences.