Kyoto Congestive Heart Failure Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 4,056
- 试验地点
- 1
- 主要终点
- hospital mortality
研究概览
简要总结
The purpose of this study is to investigate the patient characteristics, selection of treatment, and factors associated with clinical outcomes in Japanese patients with acutely decompensated congestive heart failure.
详细描述
Congestive heart failure (CHF) has been markedly increasing in Japan due to the rapid aging of the society and the Westernization of lifestyle that facilitates the development of coronary artery disease. The prognosis of patients with CHF still remains poor, despite the recent advances in medical and surgical treatment. Elderly heart failure patients with preserved ejection and multiple comorbidity may account for significant portion among CHF patients in the real world clinical practice, however; most of previous prospective cohort studies excluded these patients. The KCHF registry, an all-comer, prospective, multicenter registry, was designed to investigate all patients who admitted to the hospital due to acutly decompensated CHF. The aim of this study was to clarify the patients characteristics , selection of treatment, and prognosis of patients with acutly decompensated CHF in the real-world clinical practice in Japan.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients who admitted to the participating centers due to acutly decompensated CHF defined by modified Framingham criteria
- •Patients who underwent heart failure treatment including intravenus drug
排除标准
- 未提供
结局指标
主要结局
hospital mortality
时间窗: 1-year
次要结局
- functional level at discharge measured by NYHA classification(1-year)
- improvement of dyspnea level at discharge measured by Likert scale(1-year)
- walking ability at discharge categorized by ambulatory, wheelchair (outdoor only), wheelchair (outdoor and indoor), bedridden(1-year)
- any stroke during hospitalization(1-year)
- bleeding events during hospitalization (GUSTO definition; moderate to severe)(1-year)
- any severe ventricular arrhythmic event during hospitalization(1-year)
- onset of atrial fibrillation events during hospitalization(1-year)
- change of BNP at discharge (≧30% compared to BNP at admission )(1-year)
- usage of guideline recommended medicine during hospitalization(1-year)
- usage of tolvaptan during hospitalization(1-year)
- worsening renal function at discharge (raise of Cr≧0.3mg/dl compared to Cr at admission )(1-year)
- any bradyarrhythmic event during hospitalization(1-year)
- any cardiac surgery during hospitalization(1-year)
- any device implantation during hospitalization(1-year)
- adverse drug events during hospitalization(1-year)
- infectious diseases during hospitalization(1-year)
- any cateter intervention during hospitalization(1-year)
研究者
Takeshi Morimoto
Professor of Medicine
Kyoto University, Graduate School of Medicine