Short and Long-term Outcomes After Transplantation With Hyper-reduced Liver Grafts in Low-Weight Pediatric Recipients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- Overall survival at 1 year.
研究概览
简要总结
The shortage of organs has always been a problem in pediatric liver transplants due to the lack of donors with an adequate size. Different techniques of hepatic reduction have been described that allow to use larger organs in the pediatric population. However, in these techniques the maximum reduction achieved by segments 2 and 3 is excessive for low-weight children. Since 1997 the liver transplantation group at Hospital Italiano de Buenos Aires has developed and practiced a technique called hepatic hyper-reduction, which consists in reducing the lateral segment of a living donor, adapting the shape and size of the graft to the needs of the recipient. The investigators have performed approximately 50 pediatric liver transplants with live donors in low weight children in whom the hyper-reduction technique has been applied. The aim of the present study is to describe postoperative morbidity and mortality and analyze overall and graft survival.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 5 Months 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •< or = 17 years old.
- •Having undergone live donor liver transplantation.
- •Having received hyper-reduced liver grafts
- •At the Liver Transplantation Unit of the Hospital Italiano de Buenos Aires
- •Between June 1997 and April 2018
排除标准
- •> 17 years old.
- •Cadaveric liver transplant
- •Whole liver grafts.
结局指标
主要结局
Overall survival at 1 year.
时间窗: Overall survival wil be reported at 1 year after liver transplantation.
Overall survival was defined as the time from surgery to death (all causes) or date of last follow-up, measured in months.
Graft survival at 10 years.
时间窗: Graft survival wil be reported at 10 years after liver transplantation.
Graft survival was defined as the time from surgery to the date of re-transplantation or re-entry to waiting list, measured in months.
Overall survival at 10 years.
时间窗: Overall survival wil be reported at 10 years after liver transplantation.
Overall survival was defined as the time from surgery to death (all causes) or date of last follow-up, measured in months.
Graft survival at 3 years.
时间窗: Graft survival wil be reported at 3 years after liver transplantation.
Graft survival was defined as the time from surgery to the date of re-transplantation or re-entry to waiting list, measured in months.
Graft survival at 1 year.
时间窗: Graft survival wil be reported at 1 year after liver transplantation.
Graft survival was defined as the time from surgery to the date of re-transplantation or re-entry to waiting list, measured in months.
Overall survival at 3 years.
时间窗: Overall survival wil be reported at 3 years after liver transplantation.
Overall survival was defined as the time from surgery to death (all causes) or date of last follow-up, measured in months.
次要结局
未报告次要终点
研究者
MICAELA RAICES
Principal Investigator
Hospital Italiano de Buenos Aires