Early and Late Complications of Living Related Pediatric Liver Transplantation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Liver Transplant; Complications
- Sponsor
- Assiut University
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- hematological ,vascular and infectious complications
- Last Updated
- 6 years ago
Overview
Brief Summary
Liver transplant is the treatment of choice in children with end-stage liver failure.liver transplant is indicated when the risk of mortality from the native liver disease outweighs the overall risk of transplantation.The complications occur both immediately post-transplantation and in the long-term. The main complications in the immediate postoperative period are related to the function of the graft (dysfunction and rejection), the surgical technique, infections (bacterial, fungal, and viral),and systemic problems (pulmonary, renal, or neurological) and in the long term, the complications are typically a consequence of the prolonged immunosuppressive therapy.
Detailed Description
Liver transplant is the treatment of choice in children with end-stage liver failure. It involves the surgical removal of the entire organ, which is then replaced with a healthy donor liver. Having a healthy liver is essential to longevity because the liver is responsible for nutrient distribution and toxin removal in the body . Living-donor liver transplantation has been developed to address the disparity between the number candidates for transplant and the reduced number of available organs for liver transplantation. In general, liver transplant (LT) is indicated when the risk of mortality from the native liver disease outweighs the overall risk of transplantation. Indications for liver transplantation in children include malignant and non-malignant conditions. The complications occur both immediately post-transplantation and in the long-term. The main complications in the immediate postoperative period are related to the function of the graft (dysfunction and rejection), the surgical technique, infections (bacterial, fungal, and viral),and systemic problems (pulmonary, renal, or neurological) and In the long term, the complications are typically a consequence of the prolonged immunosuppressive therapy.
Investigators
Ahmed Mohamed Najeb Mohamed
principal investigator
Assiut University
Eligibility Criteria
Inclusion Criteria
- •All patients from (1- 18) years old who were prepared for liver transplantation and followed up at Yassin Abdel Ghaffar charity center for liver disease and research,Cairo,Egypt. from January 2015 to the end of March 2020.
Exclusion Criteria
- •Any patient who did not survive beyond the first post operative day.
Outcomes
Primary Outcomes
hematological ,vascular and infectious complications
Time Frame: 5 years
Number of patients have vascular complications Number of patients have pancytopenia Number of patients have bacterial viral or fungal infection any changes in septic screen of the patient