Arterial function and lipid profile in cardiovascular and nephrological diseases - vascular database

Recruiting

• Conditions: I70.9; I25.0; Generalized and unspecified atherosclerosis; Atherosclerotic cardiovascular disease, so described

• Registration Number: DRKS00014037
• Lead Sponsor: Medical University Brandenburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

Patients with cardiovascular risk factors, suspicion of cardiovascular disease or known cardiovascular disease

Exclusion Criteria

Acute infectious disease, active cancer, inability to give written informed consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Dysfunctional HDL is a risk factor for arteriosclerosis and correlates with IMT (intima-media-thickness) and with FMD independent of HDL-C (primary endpoint).<br>- Dysfunctional HDL correlates with the occurrence of coronary heart disease and peripheral arterial disease<br>- Dysfunctional HDL is a prognostic marker of cardiovascular events (stroke, myocardial infarction, congestive heart failure hospitalization, death) in patients with subclinical or manifest atherosclerotic disease

Secondary Outcome Measures

Name	Time	Method
- Identification of new mechanisms in the immunopathogenesis of arteriosclerosis<br>- Dysfunctional HDL is a marker of endothelial dysfunction (measured by the FMD)