Physiological MRI for precision radiotherapy of IDH-wildtype glioblastoma

• Conditions: brain tumor; glioblastoma; 10029211

• Registration Number: NL-OMON51604
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

• Informed consent;
• Adults (18 years or older);
• diagnosed with IDH-wildtype GBM, as confirmed by pathology including
molecular analysis post resection/biopsy;
• referred to outpatient clinic of the Department of Radiotherapy to undergo
standard treatment with high-dose RT.
• Patients eligible for 30x2Gy or 15x2.67Gy

Exclusion Criteria

• Contraindication for MRI
• Contraindication for use of gadolinium-based contrast agent (i.e. subject
having renal deficiency)
• Unable to give informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Equal prediction of pattern of failure (locations of tumour recurrence) based<br /><br>on the physiological CTV compared to the standard CTV used for radiotherapy<br /><br>planning, with the physiological CTV being smaller in volume. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>