Comparison of Efficacy of Ivabradine Versus Metoprolol

Phase 4

• Conditions: Coronary Artery Disease
• Interventions: Drug: Ivabradine and Metoprolol

• Registration Number: NCT01755663
• Lead Sponsor: Col. Suthee Panichkul

Brief Summary

Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-12-19
• Study First Submitted QC: 2012-12-21
• Study First Posted: 2012-12-24
• Status Verified: 2014-10
• Last Update Submitted: 2014-10-27
• Last Update Posted: 2014-10-29
• Study Start: 2014-12
• Primary Completion: 2014-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• elective patient on scheduled for 640 slices CT coronary at Phramonkutklao hospital
• Resting heart rate > 70 BPM
• age > 18 years and informed consent

Exclusion Criteria

• Heart rate > 100 BPM
• BP <100/60 mmHg
• recent congestive heart failure in 1 mo.
• SA node, AV node disease and AF
• on permanent pacemaker
• CrCL < 15ml/min. , AST or ALT > 3x UNL
• on HR reducing drug such as diltiazem, verapamil, digitalis
• contraindication for ivabradine or metoprolol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
metoprolol	Ivabradine and Metoprolol	Metoprolol (100) 1/2 tab bid pc for 3 day and the day of CT coronary , and placebo of ivabradine
Ivabradine	Ivabradine and Metoprolol	Patients will recieved ivabradine(5) 1 tab bid pc for 3 day and the day of CT, and recieve placebo of metoprolol

Primary Outcome Measures

Name	Time	Method
Heart rate of patient before CT coronary	1 January 2013 to 31 december 2013

Secondary Outcome Measures

Name	Time	Method
safety and side effect of Metoprolol and Ivabradine	1 january 2013 to 31 december 2013

Trial Locations

Locations (1)

Phramonkutklao Hospital; 🇹🇭 Bangkok, Thailand