A preliminary study on the effect of photothermal laser therapy on the vascularization and innervation of psoriatic lesions*

Recruiting

• Conditions: Psoriasis; Psoriasis Vulgaris; 10014982

• Registration Number: NL-OMON54478
• Lead Sponsor: ZBC Multicare B.V.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

18 - 69 years of age
- Psoriasis vulgaris
- Skin type I - III
- At least two lesions with of surface area of 3 cm2
- Contralateral psoriasis vulgaris lesions located on at least one of the
following locations:
* trunk
* upper arms
* upper legs

Exclusion Criteria

The participant receives other treatments for psoriasis or affecting during the
study or two weeks before the start of the study

The participant suffers from any known neurological, vascular, or immunological
condition other than psoriasis.

The participant is allergic to lidocain

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is the difference in ratio between linear nerve<br /><br>density to linear blood vessel density between the pre-treatment, and<br /><br>post-treatment biopsies. This will be named the recovery ratio (nerves/blood<br /><br>vessels). The tested hypothesis is that laser therapy results in a decrease in<br /><br>nerve fibre density.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary objective is to assess any relationship between the dermal<br /><br>architecture (in terms of blood vessels and nerves) and leukocyte infiltration<br /><br>before and after SPT treatment.</p><br>