Effect of melatonin and clonidine on postoperative delirium
- Conditions
- Delirium.Delirium, unspecified
- Registration Number
- IRCT20170316033099N7
- Lead Sponsor
- Birjand University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 150
Patients undergoing major elective orthopedic surgery
Age above 65 years
Informed consent for participation
Abbreviated mental test score below 8
Blood pressure lower than 100 millimeters of mercury
History of depression that has resulted in hospitalization or use of psychiatric drugs
Dementia
History of head trauma causing hematoma or dementia
History of tumor and cerebral infarction
History of common disorders of the glands such as hyperthyroidism and hypothyroidism
Chronic metabolic disorders
History of head and neck radiotherapy
History of poisoning with heavy metals and carbon monoxide
Alcohol consumption for more than a year
Chronic liver and kidney disease
Presence of chronic infectious diseases
Consumption of psychiatric and hypnotic drugs on a regular basis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Delirium. Timepoint: 24, 48, and 72 hours after syrgery. Method of measurement: abbreviated mental test and mini-mental state examination.
- Secondary Outcome Measures
Name Time Method