The Effect of Breaking Prolonged Sitting on Adipose Tissue and Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 主要终点
- Incremental area under curve (iAUC) for insulin
研究概览
简要总结
The purpose of this project is to investigate the effect of breaking prolonged sitting on acute adipose tissue and metabolic responses.
详细描述
Pre-trial assessments:
Physical activity assessment : a combined heart rate/accelerometer monitor was worn for 7 days to assess participant's habitual physical activity energy expenditure (Actiheart, Cambridge Neurotechnology Ltd., Cambridge, UK). This was attached to the left chest via 2 adhesive ECG pads for 24 hours per day except for during showering/bathing/swimming.
Body composition analysis:
Body mass was assessed using digital scales post-void (TANITA corp., Tokyo, Japan). Waist and hip circumference was assessed based on World Health Organisation guidelines. Body composition was determined by using Dual energy X-ray absorptiometry (Discovery, Hologic, Bedford, UK). Abdominal subcutaneous and visceral adipose tissue mass was estimated from a central region between L1-L4.
Trial days:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and post-menopausal females (post-menopausal diagnosis based on consecutive absence of menstrual cycles for >12 months).
- •Aged between 35 and 64 years
- •Central overweight (waist circumference greater than 94 cm for males and 80 cm for females)
- •Weight stable for more than 3 months (no change in weight +/- 3%)
- •Non-smoker
- •Able to walk comfortably on a treadmill
排除标准
- •Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
- •Waist circumference < 94cm for male and < 80cm for female
- •Taking medications that may influence lipid or carbohydrate metabolism or immune system function
- •Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)
研究组 & 干预措施
Prolonged Sitting
Participants sat on a chair during the trial.
干预措施: Prolonged Sitting (Behavioral)
Breaking Sitting
Participants walked regularly during the trial.
干预措施: Breaking Sitting (Behavioral)
结局指标
主要结局
Incremental area under curve (iAUC) for insulin
时间窗: 330 minutes
次要结局
- Changes in Interleukin-6 (IL-6), leptin and adiponectin protein secretion from adipose tissue explants(Before the 1st meal and 120 min after the 2nd meal (330 minutes).)
- Changes in gene expression in the adipose tissue(Before the 1st meal and 120 min after the 2nd meal (330 minutes).)
- Changes in insulin, glucose, TAG and NEFA in blood(330 minutes)
- Changes in serum Interleukin-6 (IL-6), leptin and adiponectin(330 minutes)
研究者
Yung-Chih Chen
PhD student
University of Bath