Diffuse noxious inhibitory controls in chronic cough

Completed

• Conditions: Chronic cough; Respiratory

• Registration Number: ISRCTN31901405
• Lead Sponsor: niversity Hospitals of South Manchester NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04-07
• Last Update Posted: 27 February 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Healthy volunteers:
1. Aged over 18 years old, either sex
2. Normal lung function
3. No current or past history of chronic cough or chronic respiratory illness
4. No current or past history of chronic pain, irritable bowel syndrome or chronic headaches
5. No current or past history of psychiatric illness
6. No current history of reflux disease or post-nasal drip syndrome

Chronic cough patients:
1. Aged over 18 years old, either sex
2. Chronic cough, defined as a cough lasting longer than 8 weeks despite investigation and/or treatment trials for cough variant asthma, post-nasal drip and gastro-oesophageal reflux disease
3. Normal chest x-ray
4. Normal lung function
5. Can safely omit long-acting bronchodilators (if taking)

Exclusion Criteria

1. Recent upper respiratory tract infection (less than 4 weeks)
2. Pregnancy or breastfeeding
3. Use of angiotensin converting enzyme (ACE) inhibitors
4. Any centrally acting medication which could alter the sensitivity of the cough reflex
5. History of drug or alcohol abuse
6. Current smoker or ex-smoker with greater than 10 pack year smoking history

Study & Design

• Study Type: Interventional
• Study Design: Not specified