Relevance of DNIC (diffuse noxious inhibitory Control) for pain and hyperalgesia following an incision in healthy volunteers.
Not Applicable
- Conditions
- ENDOGENESCHMERZHEMMUNGUNDSENSITISIERUNGDIEZUAKUTEUNDCHRONSICHESCHMERZENFHRENKNNE
- Registration Number
- DRKS00014291
- Lead Sponsor
- niversitätsklinikum Münster, Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 24
Inclusion Criteria
healthy, male volunteers
Exclusion Criteria
Patients under 18 years of age, intake of analgesics or psychopharmaca, chronic pain condition, neurological condition, diabetes mellitus, hypertension
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in spontaneous pain after incision (evaluated with numeric rating scale 0-100 directly after incision) by comparing incisional pain with parallel activation of conditioned pain modulation (contralateral Hand in a noxious cold water bath during incision) and incisional pain without parallel activation of conditioned pain modulation (contralateral hand in a non-noxious lukewarm water bath during incision).
- Secondary Outcome Measures
Name Time Method Correlation between Conditioned Pain Modulation and thermal and mechanical thresholds and mechanical pain sensitivity before and 1, 3, 9 and 27 hours after induction of the experimental incision; Differences between incison during CPM and without CPM regarding the above mentioned parameters before and 1, 3, 9 and 27 hours after induction of the experimental incision