Enhancing Language Learning in Ageing with Exercise.

Not Applicable

Completed

• Conditions: anguage impairments; Language impairments; Neurological - Neurodegenerative diseases; Neurological - Other neurological disorders

• Registration Number: ACTRN12617000343303
• Lead Sponsor: David Copland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-03-06
• Study Completion: 2018-04-19
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Subjects
For this study, 60 healthy older adults (age 60-85) will be recruited meeting the following criteria.

Inclusion criteria
English as primary language, low to moderate physical activity (as per International Physical Activity Questionnaire, Craig et al., 2003), doctor’s approval for participation in high intensity exercise.

Exclusion Criteria

Exclusion criteria
History of developmental learning or speech-language disorder, neurological injury or disease, mental illness, chronic severe medical illness, any contraindication to high-intensity exercise, use of hormone replacement therapy, cognitive impairment (as indicated by performance on the Montreal Cognitive Assessment (Nasreddine et al., 2005)), uncorrected hearing or vision impairments.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Performance at a computerised associative word learning task designed specifically for this trial using 15 familiar objects paired with 15 nonwords from Gupta et al. (2004). [Immediately after the single bout of exercise for initial acquisition purposes and one week later for consolidation purposes. ];Learning-related bio-marker levels in the blood will be assessed (neurotrophins and neurotransmitters). This includes dopamine, epinephrine, norepinephrine, brain-derived neurotrophic factor (BDNF), glucose, insulin, APOE, CRP, cytokine panel and lactate levels. [All three blood draws are performed within the same day (during visit 2). <br>1. Blood draw #1 : before exercising. <br>2. Acute bout of exercise (either stretching, moderate-intensity cycling or high-intensity cycling. <br>3. Blood draw #2: after exercising. <br>4. Word learning task. <br>5. Blood draw #3: after learning. <br><br>All three blood draws will be performed during visit 2 within an approximately 2 hour period. ]

Secondary Outcome Measures

Name	Time	Method
nil[nil]