Effect of intravenous versus perineural dexamethasone on random blood sugar in patients receiving brachial plexus block

Phase 2/3

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/09/057703
• Lead Sponsor: Sri Guru Ram Das Institute of Medical sciences and Research

Brief Summary

Background: Brachial plexus block is the preferred choice of anaesthesia for upper limb surgeries. Local anaesthetics like lignocaine and bupivacaine are used to provide analgesia and anaesthesia. Bupivacaine is the most commonly used local anaesthetic. Various adjuvants like clonidine, dexamethasone, opioids are used to prolong regional blockade, decrease the dosage of local anaesthetic required, shorten the onset time of block and prolong the duration of post-operative analgesia. Dexamethasone has been used as a perineural adjuvant as well as intravenous analgesic and because of its glucocorticoid properties it may cause hyperglycaemia.  Objectives: To compare the difference in blood sugar levels after the administration of dexamethasone by the perineural and intravenous route in supraclavicular brachial plexus block in non-diabetic patients undergoing upper limb surgeries. Material and methods: Total of 105 patients will receive USG guided supraclavicular brachial plexus block with 25mL of 0.5% bupivacaine. They’ll be randomly allocated to one of the three study groups of 35 each. Group I: 0.1mg/kg dexamethasone diluted in 2 mL normal saline (NS) (perineural) + 100 mL NS (Intravenous); Group II: 2 mL NS (perineural) + 0.1 mg/kg dexamethasone in 100mL NS (Intravenous); Group III: 2mL NS (perineural) + 100mL NS (Intravenous). Total volume given perineurally will be 27ml. Maximum dose of dexamethasone to be used will be 6mg. Random blood sugar will be measured at baseline (T0) and then 2, 4, 8, and 24 hours after T0. Expected Benefits: This study will help us to evaluate the effect of dexamethasone on random blood sugar levels in supraclavicular block when given intravenous vs perineurally.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-05-09
• Study Start: 2023-09-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

1.Patients in class ASA I and II 2.Surgery planned under supraclavicular block 3.Non-Diabetic Patients.

Exclusion Criteria

• Patient refusal 2.
• Infection at the site of injection 3.
• Contraindications to brachial plexus block 4.
• Pregnancy 6.
• Patient on anticoagulants 7.
• Patient on chronic/acute steroid therapy 8.
• Perioperative dextrose infusions 9.
• HbA1c >5.5 10.
• Weight of the patient <40kgs and >100kgs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in blood sugar levels at baseline & after four hours of administration of	Before performing supraclavicular brachial plexus block then at 4hrs.
dexamethasone by the perineural and intravenous route	Before performing supraclavicular brachial plexus block then at 4hrs.

Secondary Outcome Measures

Name	Time	Method
Blood sugar levels at 2,4,8 & 24 hours after dexamethasone administration.	Duration of analgesia of the three groups

Trial Locations

Locations (1)

Sri Guru Ram Das Institute of Medical Sciences and Research; 🇮🇳 Amritsar, PUNJAB, India

Sri Guru Ram Das Institute of Medical Sciences and Research

🇮🇳Amritsar, PUNJAB, India

Dr Ruchi Gupta

Principal investigator

9814020805

drruchisgrd@gmail.com