Effect of dexmedetomidine on cerebral autoregulation during general anaesthesia

Phase 3

Completed

• Conditions: ASA I, UNDERGOING LUMBAR LAMINECTOMY WITH NO INTRACRANIAL PATHOLOGY

• Registration Number: CTRI/2015/06/005875
• Lead Sponsor: AIIMS

Brief Summary

Dexmedetomidine(DEX) has been shown to provide good perioperative haemodynamic stability withdecreased intraoperative opioid requirements. It may have neural protectiveeffects, and thus may be a suitable anaesthetic adjuvant to neurosurgicalanaesthesia.Dexmedetomidine caused a dose-related reduction in both CBF andCMR in healthy subjects. anticipated adverse effects of dexmedetomidine on thecerebral oxygen supply– demand relation, *i.e.*, the CBF/CMR ratio, werenot apparent during either normocapnia or hypocapnia. The data contradict thoseof previous investigations in dogs that indicated that dexmedetomidine does notcause a reduction in CMR.The effect of dexmedetomidine on autoregulation has not beenwell studied,especially in the context of its use as an anaesthetic adjuvantand its documented effect of reduction of the cerebral blood flow, which may beof clinical relevance in the intraoperative context. Therefore this study wasdesigned to study the effect of dexmedetomidine on cerebral autoregulationduring its use as an anaesthetic adjuvant.

Primary outcome:

1.     to study the effect ofdexmedetomidine as an anaesthetic adjuvant on cerebral autoregulationand CO2 reactivity using transcranialdoppler

Secondary outcomes:

1.     effect of dexmedetomidine onintraoperative haemodynamic parameters during various stages of anaesthesia

2.     anaesthetic agent consumption

3.     time to recovery, extubationand quality of emergence

4.     side effects andcomplications noted with the technique

Detailed Description

Not available

Study Timeline

• Study Start: 2013-12-12
• Last Update Posted: 2016-05-01

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

adults aged 18-60 years who present for lumbosacral spine surgery.

Exclusion Criteria

1.Refusal of consent 2.Pregnancy 3.Morbid obesity 4.Patients with comorbidities, ASA II and above , including cardiac rhythm abnormalities 5.Addictions(smoking/regular alcohol intake/IV drug abuse) 6.Drug intake(OCPs/SSRIs/TCAs/anticonvulsants/statins etc.) 7.Carotid disease/history of syncope/dizziness 8.Hyperlipidemia.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.to study the effect of dexmedetomidine as an anaesthetic adjuvant on cerebral autoregulation and CO2 reactivity using transcranial doppler	5 mins after induction of anesthesia when BIS stable between 40-50.

Secondary Outcome Measures

Name	Time	Method
1.effect of dexmedetomidine on intraoperative haemodynamic parameters during various stages of anaesthesia	2.anaesthetic agent consumption

Trial Locations

Locations (1)

NEURO OT, CARDIO NEURO CENTER, AIIMS NEW DELHI; 🇮🇳 South, DELHI, India

NEURO OT, CARDIO NEURO CENTER, AIIMS NEW DELHI

🇮🇳South, DELHI, India

SUJOY BANIK

Principal investigator

9990013004

drsujoyb@gmail.com