Subtype-Specific Catheter-Related Bloodstream Infection Risk Factors in Hospitalized Patients With Intestinal Failure: A Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 321
- 试验地点
- 1
- 主要终点
- incidence rate of catheter-related bloodstream infection
研究概览
简要总结
This retrospective cohort study aims to identify risk factors for catheter-related bloodstream infections (CRBSIs) in hospitalized patients with intestinal failure (IF), including all subtypes (Types I-III). The study included 321 patients with 9,365 catheter-days. Multivariate logistic and Cox regression analyses were used to identify independent risk factors. Stratified analyses identified subtype-specific risks, and hospital stay length and health economic outcomes were assessed. The study highlights the need for subtype-tailored prevention strategies and closer metabolic and immune monitoring in hospitalized IF patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients meeting the ESPEN 2023 diagnostic criteria for intestinal failure.
排除标准
- •Catheter indwelling duration <48 hours; Implanted catheter before admission; Complex components in PN difficult to quantify; Positive blood cultures with unclear CRBSI diagnosis; Alternative infection sources identified.
结局指标
主要结局
incidence rate of catheter-related bloodstream infection
时间窗: From catheter insertion until removal or discharge, assessed up to 24 months.
frequency of catheter-related bloodstream infections occurring every 1,000 days
次要结局
- Proportion of patients with high calorie-to-nitrogen ratio(From catheter insertion until removal or discharge, assessed up to 24 months.)
- Incidence of lymphocytopenia(Baseline.)
- Proportion of patients with high parenteral nutrition energy supply(From catheter insertion until removal or discharge, assessed up to 24 months.)
- Incidence of neutropenia(Baseline)
- All-cause length of hospital stay(At the time of hospital discharge, assessed up to 24 months.)
- Total hospitalization costs(At the time of hospital discharge, assessed up to 24 months.)
研究者
Wang Xinying
Professor of Medicine
Jinling Hospital, China