Radiation-induced DNA repair mechanisms andchromosomal changes
Recruiting
- Conditions
- Radiation-induced DNA repair mechanisms and chromosomal changes
- Registration Number
- DRKS00034426
- Lead Sponsor
- niversitätsklinikum Heidelberg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Written consent to participate in the study, capacity to consent
Additionally for patients: Medically justifiable indication provided by the attending physician for radiological diagnostics/intervention for elective endovascular procedures
Additionally for staff: Proper application of the usual radiation protection measures
Exclusion Criteria
Under 18 years of age, discontinuation/refusal of radiological examination, lack of written consent from the patient, pregnancy, emergency endovascular interventions, autoimmune diseases
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Specific acute DNA repair markers, more precisely the activity determination of the y-H2A.X histone protein, are to be examined after radiation exposure. The investigated markers of the blood samples before and after radiation exposure will be compared.
- Secondary Outcome Measures
Name Time Method It is assumed that both the activity of ?-H2A.X and chronic chromosomal changes (e.g. dicentric chromosomes or chromosome translocations) correlate with the radiation dose.