Pilot Study of Biomarkers for Radiation Therapy
Suspended
- Conditions
- Cancer
- Registration Number
- NCT01050725
- Lead Sponsor
- Benaroya Research Institute
- Brief Summary
The purpose of this study is to determine whether specific assays of DNA damage repair proteins can be used in patients undergoing radiation therapy. The ultimate goal of this research is to develop clinically useful biomarkers from blood samples that could be used to customize radiation treatment for individuals, leading to reduced side effects and improved outcomes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- patients > 18 years of age with primary lung, esophageal or rectal cancer receiving neo-adjuvant chemoradiotherapy before planned resection
- patients with clinically localized prostate cancer receiving definitive radiation therapy with external beam treatment. brachytherapy as a boost and/or hormonal therapy are allowed.
- patients with head and neck, lung, esophageal or cervical cancer who will receive definitive radiotherapy
Exclusion Criteria
- prior history of chemotherapy given within 6 months before enrollment.
- prior radiotherapy or radionuclide treatment and/or brachytherapy within 6 months prior to enrollment.
- unwillingness to comply with tests, protocol, or informed consent.
- concurrent enrollment on any protocol that would require non-compliance with treatment procedures.
- chemotherapy required within 2 hours following first dose of XRT.
- PET scan done within 48 hours of first blood draw.
- nuclear medicine exposure within 4 days prior to first draw.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States