Application of an Electronic Nose in the Early Detection of ASpergillosis
Completed
- Conditions
- Pulmonary Invasive Aspergillosis
- Registration Number
- NCT01395446
- Brief Summary
The purpose of this study is to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Patients that
- are 18 years of age or older
- will undergo treatment for a hematological malignancy expected to result in grade 4 neutropenia (according to CTCAE 3.0, i.e. <0.5 x 109 neutrophils/L) of prolonged duration (i.e., more than 7 days), e.g. hematopoietic stem cell transplantation or induction/consolidation treatment for acute myeloid leukaemia
- have given written informed consent
Exclusion Criteria
- a previously diagnosed invasive mycosis
- the inability to perform the breathing manoeuvre needed for eNose-analysis of exhaled air
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method accuracy with which the Cyranose can discriminate between patients with probable or proven invasive pulmonary aspergillosis and neutropenic controls with fever 4 days The cross-validated accuracy with which the Cyranose can discriminate between patients with probable or proven invasive pulmonary aspergillosis and neutropenic controls with fever, defined as the percentage of correctly classified patients using the leave-one out method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Hematology, Academic Medical Center
š³š±Amsterdam, Netherlands