Therapeutic Efficacy of Oxcarbazepine and Sodium Valproate in Acute Mania
- Conditions
- acute mania.Mania without psychotic symptoms
- Registration Number
- IRCT201012055280N2
- Lead Sponsor
- Mashhad University of Medical Scinces
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 48
For eligibility in the study patients had to be 18 to 60 years of age and with DSM- IV- TR axis I diagnosis of BMD-I in acute manic episode.
Exclusion criteria included a primary diagnosis of Schizophrenia, delirium, anorexia nervosa, bulimia, autism, substance abuse, mental retardation and ADHD in recent 3 months. Other exclusion criteria were a history of epilepsy, a history of psychogenic polydipsia, a history of symptomatic hyponatremia and patients who were taking other antimanic medications during the study prior or within one week before it. Patients were required to be free of psychotropic drugs with exceptions of diphenhydramin or lorazapam for control of agitation and aggression. Risperidone 2-4 mg/day was prescribed for all of patients.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of mood. Timepoint: base line,weeks 3,6. Method of measurement: Young Mania rating scale.
- Secondary Outcome Measures
Name Time Method Clinical Global Impression Scale. Timepoint: base line ,weeks 3 and 6. Method of measurement: change of scores.