Administration of Human Chorionic Gonadotrophin Before Secretory Transformation of Frozen-thawed Embryo Transfer Cycles
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Live birth delivery rate (LBR)
研究概览
简要总结
Successful embryo implantation is complicated process that requires synchrony between good-quality embryos and receptive endometrium. Human chorionic gonadotropin (hCG), is one of the initial embryonic signals and the major embryoendometrial relationship regulator. This study will be conducted to to investigate the role of parenteral hCG used for the transfer of cryopreserved- thawed embryos with HRT cycles in the outcome of artificially prepared frozen embryo transfer (FET) cycles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patient age ≤ 38 years.
- •Normal 3D transvaginal ultrasound.
- •At least two good quality embryos cryopreserved by vitrification.
- •No GnRH agonists administration before FET cycle.
- •Exclusion Criteria
- •Endometriosis.
- •Uterine anomalies.
- •Evidence of hydrosalpinx by hystrosalpingography or ultrasound.
- •Evidence of immune disease, hematological or hormonal disorder.
排除标准
- 未提供
研究组 & 干预措施
HCG group
n Group 1 (hCG): participants will receive endometrial preparation with estrogen and an intramuscular hCG injection will before progesterone supplementation
干预措施: Human Chorionic Gonadotrophin Intramuscular injection 10.000 IU (Drug)
结局指标
主要结局
Live birth delivery rate (LBR)
时间窗: 7 months
Number of live births beyond 28 weeks of gestational age to the total number of FET cycles
次要结局
- Clinical pregnancy rate(2 weeks after positive pregnancy test)
- Implantation rate(2 weeks after positive pregnancy test)
- Miscarriage rate(20 weeks gestational age)