hCG Supplementation in Frozen-Thawed Embryo Transfer Cycle
Phase 2
Completed
- Conditions
- Fertility Agents, Female
- Interventions
- Drug: s.c. human chorionic gonadotropin (Ovitrelle)
- Registration Number
- NCT00398229
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
The implantation rate after frozen-thawed embryo transfer cycles depends mostly on the receptivity of the endometrium and the embryo quality.The effects of human chorionic gonadotropins (hCG) on the endometrium have been investigated for several years. hCG was shown to up-regulate gene expression during the differentiation of human endometrial stromal cells into decidua. The aim of our study was to assess the benefit of hCG supplementation throughout the secretory phase of artificial frozen-thawed embryo transfer cycles.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 300
Inclusion Criteria
- all women on frozen-thawed embryo-transfer cycle
Exclusion Criteria
- any allergy to injection of human chorionic gonadotropin before
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description B s.c. human chorionic gonadotropin (Ovitrelle) - A s.c. human chorionic gonadotropin (Ovitrelle) receiving hCG injection
- Primary Outcome Measures
Name Time Method implantation rate 4 weeks pregnancy rate 4 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hadassah Medical center
🇮🇱Jerusalem, Israel