Effect of enterally administered sleep-promoting medication on the intravenous sedative dose and its safety and cost profile in mechanically ventilated patients: a retrospective cohort study - Effect of enterally administered sleep-promoting medication on the intravenous sedative dose and its safety and cost profile in mechanically ventilated patients: a retrospective cohort study

The average daily propofol dose per body weight administered as a continuous sedative during mechanical ventilation through an oral endotracheal tube was significantly lower in the early administration group (EA group) than in the late administration (LA group) and no administration group (NA group) (Beta Coefficient -5.18 [95% CI -8.95 to -1.40], Beta Coefficient -4.51 [95% CI -8.58 to -0.44]); however, there was no difference between the LA and NA groups (Beta Coefficient 0.66 [95% CI -3.14 to 4.46]).