Physiological studies of hormones which control metabolism and reproduction
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 78
研究概览
简要总结
2020 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31628465 Effects of Peptide YY on the reproductive axis in healthy young men (added 03/12/2019) 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29974637 Effects of kisspeptin on glucose-stimulated insulin secretion, metabolites, gut hormones, appetite and food intake in healthy men (added 03/12/2019) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37039248/ Effects of kisspeptin on food intake in women with overweight or obesity (added 17/04/2023) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32232363/ Acute effects of glucagon on reproductive hormone secretion in healthy men (added 26/02/2024) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32052032/ Effects of glucagon-like peptide-1 on the reproductive axis in healthy men (added 26/02/2024)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged 18 – 60 years
- •2. Male or female
- •3. Stable body weight for the preceding 3 months
- •4. 12-lead ECG with no clinically significant abnormalities as judged by the investigators
- •5. Full blood count, urea and electrolytes, thyroid function tests, liver function tests and glucose within 2 x the upper limit of normal
- •6. Conditions that predispose subfertility: BMI >25, Pre-diabetes, Type 2 diabetes
排除标准
- •1. History of any medical, psychological or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study or potentially cause harm to the volunteer
- •2. Pregnancy or breastfeeding
- •3. History of hypersensitivity to any of the components of the infusions
- •4. Treatment with an investigational drug within the preceding 2 months
- •5. Volunteers who have or intend to donate blood or blood products within three months before or following study completion
- •6. A history of alcoholism or substance abuse within the preceding 5 years
- •7. A history of major haematological, renal, thyroid or hepatic abnormalities or significant cardiovascular disease
- •8. A history of cancer
- •9. Volunteers with a medical or psychological condition that would impair their ability to participate reliably in the study or give informed consent
- •10. Smoker