NCT01509482已完成不适用
Insulin Resistance : a New Diagnosis of the Pathogenesis of Idiopathic Oligozoospermia and Non Obstructive Azoospermia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- serum insulin
研究概览
简要总结
Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.
详细描述
During the past decade IR has been recognized as a major contributor to the pathogenesis of chronic anovulation, hyperandrogenism and metabolic abnormalities associated with PCOS . Theoretically IR in men may result in a similar reproductive abnormalities ( chronic hypospermatogenesis ) as well as other metabolic abnormalities similar to what happens in PCOS in women .
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •sperm count less than 10 million per milliliter
- •non-obstructive azoospermia
排除标准
- •high FSH ( > 10 mIU/ ml )
- •high prolactin ( > 36 mIU/ml )
- •abnormal karyotype
结局指标
主要结局
serum insulin
时间窗: one month
次要结局
- Triglycerides(One month)
- Fasting Glucose(one month)
- cholesterol(one month)
- high density lipoprotein ( HDL)(one month)
- Low density lipoprotein ( LDL )(one month)
- testosterone(one month)
研究者
Ragaa Mansour
Director, the Egyptian IVF-ET center
The Egyptian IVF-ET Center
研究点 (2)
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