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Insulin Resistance in Idiopathic Oligospermia and Azoospermia

Not Applicable
Completed
Conditions
Insulin Resistance
Azoospermia
Oligospermia
Registration Number
NCT01509482
Lead Sponsor
The Egyptian IVF-ET Center
Brief Summary

Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.

Detailed Description

During the past decade IR has been recognized as a major contributor to the pathogenesis of chronic anovulation, hyperandrogenism and metabolic abnormalities associated with PCOS . Theoretically IR in men may result in a similar reproductive abnormalities ( chronic hypospermatogenesis ) as well as other metabolic abnormalities similar to what happens in PCOS in women .

Recruitment & Eligibility

Status
COMPLETED
Sex
Male
Target Recruitment
100
Inclusion Criteria
  • sperm count less than 10 million per milliliter
  • non-obstructive azoospermia
Exclusion Criteria
  • high FSH ( > 10 mIU/ ml )
  • high prolactin ( > 36 mIU/ml )
  • abnormal karyotype
  • AZF

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
serum insulinone month
Secondary Outcome Measures
NameTimeMethod
cholesterolone month
high density lipoprotein ( HDL)one month
Low density lipoprotein ( LDL )one month
testosteroneone month
TriglyceridesOne month
Fasting Glucoseone month

Trial Locations

Locations (1)

The Egyptian IVF-ET center

🇪🇬

Cairo, Egypt

The Egyptian IVF-ET center
🇪🇬Cairo, Egypt

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