Insulin Resistance in Idiopathic Oligospermia and Azoospermia

Not Applicable

Completed

• Conditions: Insulin Resistance; Azoospermia; Oligospermia

• Registration Number: NCT01509482
• Lead Sponsor: The Egyptian IVF-ET Center

Brief Summary

Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.

Detailed Description

During the past decade IR has been recognized as a major contributor to the pathogenesis of chronic anovulation, hyperandrogenism and metabolic abnormalities associated with PCOS . Theoretically IR in men may result in a similar reproductive abnormalities ( chronic hypospermatogenesis ) as well as other metabolic abnormalities similar to what happens in PCOS in women .

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-01-06
• Study First Submitted QC: 2012-01-10
• Study First Posted: 2012-01-13
• Primary Completion: 2014-01
• Study Completion: 2014-04
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-23
• Last Update Posted: 2014-11-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 100

Inclusion Criteria

• sperm count less than 10 million per milliliter
• non-obstructive azoospermia

Exclusion Criteria

• high FSH ( > 10 mIU/ ml )
• high prolactin ( > 36 mIU/ml )
• abnormal karyotype
• AZF

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
serum insulin	one month

Secondary Outcome Measures

Name	Time	Method
cholesterol	one month
high density lipoprotein ( HDL)	one month
Low density lipoprotein ( LDL )	one month
testosterone	one month
Triglycerides	One month
Fasting Glucose	one month

Trial Locations

Locations (1)

The Egyptian IVF-ET center; 🇪🇬 Cairo, Egypt