Insulin Resistance in Idiopathic Oligospermia and Azoospermia
Not Applicable
Completed
- Conditions
- Insulin ResistanceAzoospermiaOligospermia
- Registration Number
- NCT01509482
- Lead Sponsor
- The Egyptian IVF-ET Center
- Brief Summary
Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.
- Detailed Description
During the past decade IR has been recognized as a major contributor to the pathogenesis of chronic anovulation, hyperandrogenism and metabolic abnormalities associated with PCOS . Theoretically IR in men may result in a similar reproductive abnormalities ( chronic hypospermatogenesis ) as well as other metabolic abnormalities similar to what happens in PCOS in women .
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 100
Inclusion Criteria
- sperm count less than 10 million per milliliter
- non-obstructive azoospermia
Exclusion Criteria
- high FSH ( > 10 mIU/ ml )
- high prolactin ( > 36 mIU/ml )
- abnormal karyotype
- AZF
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method serum insulin one month
- Secondary Outcome Measures
Name Time Method cholesterol one month high density lipoprotein ( HDL) one month Low density lipoprotein ( LDL ) one month testosterone one month Triglycerides One month Fasting Glucose one month
Trial Locations
- Locations (1)
The Egyptian IVF-ET center
🇪🇬Cairo, Egypt
The Egyptian IVF-ET center🇪🇬Cairo, Egypt